Direct Research units

Theses

2019
Hassan Hayek (18 octobre 2019) :
“Role du facteur d’initiation eIF3 dans la traduction de l’ARNm de l’histone H4”
Thèse de l’Université de Strasbourg
Direction : Christine Allmang-Cura et Gilbert Eriani

Antoine Creugny (15 octobre 2019) :
“Identification and functional characterization of proteins involved in the regulation of viral microRNAs”
Thèse de l’Université de Strasbourg
Direction : Sébastien Pfeffer

Fatima Alghoul (26 Sep 2019) :
“The mechanism of inhibition of cap-dependent translation by the Translation Inhibitory Elements (TIE) a3 and a11 in Hox mRNAs”
Thesis of Strasbourg university
Direction : Franck Martin

Tanja Seissler (13 Sep 2019) :
“Translational inhibition of the restriction factor APOBEC3G (A3G) by the HIV-1 Vif protein : role of a uORF in the 5’-UTR of A3G mRNA and identification of cellular factors”
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart

2018
Raphaël de Wijn (14 Dec 2018) :
“Application of new crystallization approaches and serial crystallography to the structural study of enzyme/tRNA complexes”
Thesis of Strasbourg university
Direction : Claude Sauter

Lauriane Gross (26 octobre 2018) :
“Le piratage de l’appareil de traduction de la cellule hôte par le virus de la paralysie du cricket (CrPV)”
Thèse de l’Université de Strasbourg
Direction : Franck Martin

Damien Ferhadian (28 Sep 2018) :
“Structure of the RNA in Influenza A virus ribonucleoproteins”
Thesis of Strasbourg university
Direction : Roland Marquet

Ligia Elena González-Serrano (21 Sep 2018) :
“Characterization of new properties of the human mitochondrial arginyl-tRNA synthetase and contribution to the general understanding of pathologies linked to mutations on mitochondrial aminoacyl-tRNA synthetases”
Thesis of Strasbourg university
Direction : Marie Sissler

Marta Cela Madinaveitia (20 Sep 2018) :
“tRNA import in Plasmodium : selection at the entrance ?”
Thesis of Strasbourg university
Direction : Magali Frugier

Yacine Dahman (19 Sep 2018) :
“Characterization of the nuclear RNase P of Candida glabrata and improvement of genome editing tools”
Thesis of Strasbourg university
Direction : Fabrice Jossinet

Alexis Autour (September 17, 2018) : “Improvement and screening of fluorogenic aptameric RNA properties in microfluidic systems Thesis of the University of Strasbourg Management: Michael Ryckelynck

Anthony Marchand (17 Jan 2018) :
“Exploration bioinformatique du transcriptome en pathologie humaine : applications en mycologie et en cancérologie”
Thesis of Strasbourg university
Direction : Fabrice Jossinet and Laurence Despons

Jailson Fernando Brito Querido (11 Dec 2017) :
“Structural study of mRNA translation in kinetoplastids by Cryo-electron microscopy”
Thesis of Strasbourg university
Direction : Yaser Hashem

Vanessa Dacleu Siewe (29 Nov 2017) :
“Molecular and structural bases of selenoprotein N dysfunction in diverse forms of congenital muscular dystrophies”
Thesis of Strasbourg and Saarlandes universities
Direction : Alain Lescure et Roy Lancaster

Safiatou Coulibaly (13 Oct 2017) :
“Double approach to anti-tumoral therapy with lentiviral vectors”
Thesis of Strasbourg university
Direction : Matteo Negroni

Alessandra Marenna (29 Sep 2017) :
“Staphylococcus aureus protein S1, an RNA chaperone involved in translation initiation and sRNA regulation”
Thesis of Strasbourg university
Direction : Stefano Marzi

Marine Kanja (28 Sep 2017) :
“Coevolution within HIV-1 pol gene : a crossroads at the borders of new HIV species”
Thesis of Strasbourg university
Direction : Matteo Negroni

Elodie Mailler (22 Sep 2017) :
“Structural rearrangements of HIV-1 genomic RNA during maturation of the viral particle”
Thesis of Strasbourg university
Direction : Roland Marquet and Valérie Vivet-Boudou

Delphine Mege-Bronesky (21 Sep 2017) :
“Non-coding RNAs at the heart of sugar metabolism : new mechanisms and impact on adaptation and virulence”
Thesis of Strasbourg university
Direction : Pascale Romby

2016
Tina Muller-Jühling (14 Dec 2016) :
“Structure, function & evolution of armless mitochondrial tRNAs”
Thesis of Strasbourg and Leipzig universities
Direction : Catherine Florentz et Mario Mörl

Pierre Cappy (2 Dec 2016) :
“Recombination patterns, genesis and functionality of HIV-1/MO recombinants: exploring the frontiers of new HIV species”
Thesis of Rouen Normandie university
Direction : Jean-Christophe Plantier and Matteo Negroni

Loukmane Karim (4 Oct 2016) :
“Submitochondrial organization of human mitochondrial aspartyl-tRNA synthetase and its implication in LBSL disease”
Thesis of Strasbourg university
Direction : Marie Sissler

Camille Libre (30 Sep 2016) :
“Translational control of APOBEC3G/F restriction factors by the HIV-1 Vif protein”
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart

D’Ascenzo Luigi (29 Sep 2016) :
“Atomic-scale investigation of recognition networks in RNA and RNA/protein systems”
Thesis of Strasbourg university
Direction : Pascal Auffinger

Marie Gerber (27 Sep 2016) :
“Identification of specific packaging signals in influenza A viruses genome”
Thesis of Strasbourg university
Direction : Roland Marquet et Catherine Isel

Benoît Meyer (26 Sep 2016) :
“Thermodynamic study of the translation initiation and elongation in Escherichia coli”
Thesis of Strasbourg university
Direction : Eric Ennifar and Philippe Dumas

Delphine Kapps (23 Sep 2016) :
“Role of host’s transfer RNA import in Plasmodium development”
Thesis of Strasbourg university
Direction : Magali Frugier

Arnaud Tomasini (16 Sep 2016) :
“Identification of Staphylococcus aureus non coding RNAs primary targets and their associated regulatory networks : developping the MAPS and Grad-seq approaches “
Thesis of Strasbourg university
Direction : Pascale Romby

Semih Cetin (12 Sep 2016) :
“Molecular characterisation of the mechanism of target-dependant microRNA degradation”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer

Romain Gasser (13 Jun 2016) :
“Understanding the genetic flexibility of the HIV-1 envelope protein through the study of the network of its coevolving amino acids”
Thesis of Strasbourg university
Direction : Matteo Negroni

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Theses

2019
Hassan Hayek (18 Oct 2019) :
“Role du facteur d’initiation eIF3 dans la traduction de l’ARNm de l’histone H4”
Thesis of Strasbourg university
Direction : Christine Allmang-Cura and Gilbert Eriani Antoine Creugny (15 Oct 2019) :
“Identification and functional characterization of proteins involved in the regulation of viral microRNAs”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer Fatima Alghoul (26 Sep 2019) :
“The mechanism of inhibition of cap-dependent translation by the Translation Inhibitory Elements (TIE) a3 and a11 in Hox mRNAs”
Thesis of Strasbourg university
Direction : Franck Martin Tanja Seissler (13 Sep 2019) :
“Translational inhibition of the restriction factor APOBEC3G (A3G) by the HIV-1 Vif protein : role of a uORF in the 5’-UTR of A3G mRNA and identification of cellular factors”
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart 2018
Raphaël de Wijn (14 Dec 2018) :
“Application of new crystallization approaches and serial crystallography to the structural study of enzyme/tRNA complexes”
Thesis of Strasbourg university
Direction : Claude Sauter Lauriane Gross (26 Oct 2018) :
“Le piratage de l’appareil de traduction de la cellule hôte par le virus de la paralysie du cricket (CrPV)”
Thesis of Strasbourg university
Direction : Franck Martin Damien Ferhadian (28 Sep 2018) :
“Structure of the RNA in Influenza A virus ribonucleoproteins”
Thesis of Strasbourg university
Direction : Roland Marquet Ligia Elena González-Serrano (21 Sep 2018) :
“Characterization of new properties of the human mitochondrial arginyl-tRNA synthetase and contribution to the general understanding of pathologies linked to mutations on mitochondrial aminoacyl-tRNA synthetases”
Thesis of Strasbourg university
Direction : Marie Sissler Marta Cela Madinaveitia (20 Sep 2018) :
“tRNA import in Plasmodium : selection at the entrance ?”
Thesis of Strasbourg university
Direction : Magali Frugier Yacine Dahman (19 Sep 2018) :
“Characterization of the nuclear RNase P of Candida glabrata and improvement of genome editing tools”
Thesis of Strasbourg university
Direction : Fabrice Jossinet Alexis Autour (17 Sep 2018) :
“Screening and improving light-up RNA aptamer properties using droplet-based microfluidics”
Thesis of Strasbourg university
Direction : Michael Ryckelynck Anthony Marchand (17 Jan 2018) :
“Exploration bioinformatique du transcriptome en pathologie humaine : applications en mycologie et en cancérologie”
Thesis of Strasbourg university
Direction : Fabrice Jossinet and Laurence Despons 2017
Jailson Fernando Brito Querido (11 Dec 2017) :
“Structural study of mRNA translation in kinetoplastids by Cryo-electron microscopy”
Thesis of Strasbourg university
Direction : Yaser Hashem Vanessa Dacleu Siewe (29 Nov 2017) :
“Molecular and structural bases of selenoprotein N dysfunction in diverse forms of congenital muscular dystrophies”
Thesis of Strasbourg and Saarlandes universities
Direction : Alain Lescure et Roy Lancaster Safiatou Coulibaly (13 Oct 2017) :
“Double approach to anti-tumoral therapy with lentiviral vectors”
Thesis of Strasbourg university
Direction : Matteo Negroni Alessandra Marenna (29 Sep 2017) :
“Staphylococcus aureus protein S1, an RNA chaperone involved in translation initiation and sRNA regulation”
Thesis of Strasbourg university
Direction : Stefano Marzi Marine Kanja (28 Sep 2017) :
“Coevolution within HIV-1 pol gene : a crossroads at the borders of new HIV species”
Thesis of Strasbourg university
Direction : Matteo Negroni Elodie Mailler (22 Sep 2017) :
“Structural rearrangements of HIV-1 genomic RNA during maturation of the viral particle”
Thesis of Strasbourg university
Direction : Roland Marquet and Valérie Vivet-Boudou Delphine Mege-Bronesky (21 Sep 2017) :
“Non-coding RNAs at the heart of sugar metabolism : new mechanisms and impact on adaptation and virulence”
Thesis of Strasbourg university
Direction : Pascale Romby 2016
Tina Muller-Jühling (14 Dec 2016) :
“Structure, function & evolution of armless mitochondrial tRNAs”
Thesis of Strasbourg and Leipzig universities
Direction : Catherine Florentz et Mario Mörl Pierre Cappy (2 Dec 2016) :
“Recombination patterns, genesis and functionality of HIV-1/MO recombinants: exploring the frontiers of new HIV species”
Thesis of Rouen Normandie university
Direction : Jean-Christophe Plantier and Matteo Negroni Loukmane Karim (4 Oct 2016) :
“Submitochondrial organization of human mitochondrial aspartyl-tRNA synthetase and its implication in LBSL disease”
Thesis of Strasbourg university
Direction : Marie Sissler Camille Libre (30 Sep 2016) :
“Translational control of APOBEC3G/F restriction factors by the HIV-1 Vif protein “
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart D’Ascenzo Luigi (29 Sep 2016) :
“Atomic-scale investigation of recognition networks in RNA and RNA/protein systems”
Thesis of Strasbourg university
Direction : Pascal Auffinger Marie Gerber (27 Sep 2016) :
“Identification of specific packaging signals in influenza A viruses genome”
Thesis of Strasbourg university
Direction : Roland Marquet et Catherine Isel Benoît Meyer (26 Sep 2016) :
“Thermodynamic study of the translation initiation and elongation in Escherichia coli”
Thesis of Strasbourg university
Direction : Eric Ennifar and Philippe Dumas Delphine Kapps (23 Sep 2016) :
“Role of host’s transfer RNA import in Plasmodium development”
Thesis of Strasbourg university
Direction : Magali Frugier Arnaud Tomasini (16 Sep 2016) :
“Identification of Staphylococcus aureus non coding RNAs primary targets and their associated regulatory networks : developping the MAPS and Grad-seq approaches “
Thesis of Strasbourg university
Direction : Pascale Romby Semih Cetin (12 Sep 2016) :
“Molecular characterisation of the mechanism of target-dependant microRNA degradation”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer Romain Gasser (13 Jun 2016) :
“Understanding the genetic flexibility of the HIV-1 envelope protein through the study of the network of its coevolving amino acids”
Thesis of Strasbourg university
Direction : Matteo Negroni 2015
Jérôme Basquin (21 Dec 2015) :
“Structural study of the complex CCR4-NOT”
Thesis of Strasbourg university
Direction : Claude Sauter

Mélodie Duval (6 Nov 2015) :
“Escherichia coli ribosomal protein S1 at the crossroad between translation and gene expression”
Thesis of Strasbourg university
Direction : Pascale Romby

Joelle Mezher (29 Sep 2015) :
“Innate immunity and viral countermeasures : structural and biophysical studies of the complex formed between the human cytidine deaminase APOBEC3G/F and the HIV-1 viral infectivity factor Vif”
Thesis of Strasbourg university
Direction : Eric Ennifar

Anne-Sophie Gribling-Burrer (25 september 2015) :
“Mechanism of selenoprotein mRNA 5’cap hypermethylation and impact on their translation”
Thesis of Strasbourg university
Direction : Christine Allmang-Cura

2014
Delphine Parmentier (27 Oct 2014) :
“Function of Tex in Staphylococcus aureus : a potentiel link with regulatory RNAs?”
Thesis of Strasbourg university
Direction : Pascale Romby

Mickael Briens (24 october 2014) :
“Raie of selenoprotein N in redox regulation networks : physiological and transcriptomic studies”
Thesis of Strasbourg university
Direction : Alain Lescure

Contrant Maud (26 Sep 2014) :
“Regulation of the expression of Kaposi’s sarcoma associated herpesvirus microRNAs”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer

Jana Alexandrova (19 Sep 2014) :
“Tissue-specific expression of human Glycyl-tRNA synthetase: Connection with the Charcot-Marie Tooth disease”
Thesis of Strasbourg university
Direction : Magali Frugier

Franziska Pinker (15 Sep 2014) :
“Structural characterization of proteinaceous RNase P from Arabidopsis thaliana”
Thesis of Strasbourg university
Direction : Claude Sauter and Philippe Giegé

2013
Arnaud D’orchymont (27 Nov 2013) :
“Structural studies of histone H4 messenger RNA”
Thesis of Strasbourg university
Direction : Jean Cavarelli and Gilbert Eriani

Santiago Guerrero (25 Oct 2013) :
“Role of HIV-1 Vif in viral replication: translational regulation of APOBEC3G/F and RNA chaperone activity”
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart

Hagen Schwenzer (21 Oct 2013) :
“New properties of mitochondrial aminoacyl-tRNA synthétases and their connection to mitochondrial diseases”
Thesis of Strasbourg university
Direction : Marie Sissler and Catherine Florentz

Patrick Barhoum (30 Sep 2013) :
“Synthesis and characterization of new fluorescent probes and chemical reagents for structural analysis of RNA”
Thesis of Strasbourg university
Direction : Valérie Vivet-Boudou

Patryk Ngondo (24 Sep 2013) :
“Characterization of the regulatory potential of the transcription factor ZNF143”
Thesis of Strasbourg university
Direction : Philippe Carbon

Mélanie Meyer (13 Sep 2013) :
“Contributions to the study of the architecture and evolution of ribozymes”
Thesis of Strasbourg university
Direction : Benoît Masquida

Guillaume Suffert (7 May 2013) :
“Regulation of apoptosis by Kaposi’s sarcoma associated herpesvirus microRNAs”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer and Olivier Voinnet

Franck Jühling (21 Jan 2013) :
“Structure and evolution of animal mitochondrial tRNAs”
Thesis of Strasbourg and Leipzig universities
Direction : Catherine Florentz and Peter Stadler

2012
Frédéric Fischer (28 Sep 2012) :
“Mechanisms and evolution of the ribonucleoprotein complexes involved in the tRNA-dependent amino acid biosynthesis”
Thesis of Strasbourg university
Direction : Daniel Kern and Hubert Becker

Meriem Hamoudi (21 Sep 2012) :
“Genetic and structural constraints for the generation of HIV-1 recombinant envelopes”
Thesis of Strasbourg university
Direction : Matteo Negroni

Cédric Romilly (14 Sep 2012) :
“Function of novel non coding RNAs in gene regulation in Staphylococcus aureus : adaptation to environment and virulence”
Thesis of Strasbourg university
Direction : Pascale Romby

Pierre Cattenoz (5 Jun 2012) :
“Characterization of Alu element expression and A-to-I RNA editing in mammals”
Thesis of Strasbourg university and Central Queensland Univ.-Rockhampt.(Aus)
Direction : Eric Westhof and John Mattick

Sondes Guedich (Jun 2012) :
“Development of a microfluidic approach to study the kinetics of folding of regulatory RNA”
Thesis of Strasbourg and Sfax (Tunisie) universities
Direction : Dominique Burnouf, Philippe Dumas and Hafedh Mejdoub

Ekram Wassim (26 Jan 2012) :
“Molecular mechanisms governing the selective packaging of HIV-1 genomic RNA”
Thesis of Strasbourg university
Direction : Roland Marquet and Jean-Christophe Paillart

Mélanie Tanguy (31 Oct 2011) :
“Regulation of cellular and viral microRNAs accumulation upon mouse cytomegalovirus infection”
Thesis of Strasbourg university
Direction : Sébastien Pfeffer and Olivier Voinnet

Nizar Saad (7 Oct 2011) :
“Identification and analysis of a T-Box regulatory element controlling the expression of the enzymes involved in the tRNA dependent synthesis of asparagine in Clostridium acetobutylicum”
Thesis of Strasbourg university
Direction : Hubert Becker and Daniel Kern

Olga Kossinova(30 Sep 2011) :
“Insights into the selenocysteine incorporation mechanism in mammals”
Thesis of Strasbourg university
Direction : Alain Krol and Galina Karpova

Séverine Freisz (28 Sep 2011) :
“Structural studies of the interaction between apobec3 human cytidine deaminase and the HIV-1 viral infectivity factor (VIF)”
Thesis of Strasbourg university
Direction : Eric Ennifar

Cyrille Gavazzi (26 Sep 2011) :
“Mechanism of incorporation of vRNAs segments of an avian influenza A virus : comparison with a human virus and implications for genetic reassortment “
Thesis of Strasbourg university
Direction : Roland Marquet and Bruno Lina

José António Almeida Costa da Cruz (20 Sep 2011) :
“Development of evolutionary models for non-coding RNAs”
Thesis of Strasbourg university
Direction : Eric Westhof

Maya Ayach (16 Sep 2011) :
“Host-parasite interaction : mechanism of inhibition of human protein synthesis by the circumsporozoite protein of Plasmodium falciparum, malaria’s agent”
Thesis of Strasbourg university
Direction : Magali Frugier and Joëlle Rudinger-Thirion

2010
Lucile Sinck (29 Nov 2010) :
“Dimerization of the human immunodeficiency virus type 1 genomic RNA : functions in selective packaging and splicing”
Thesis of Strasbourg university
Direction : Jean-Christophe Paillart

Emilie Fournier (19 Nov 2010) :
“Incorporation sélective des segments d’ARN génomiques du virus influenza A : vers une compréhension des mécanismes moléculaires”
Thesis of Strasbourg university
Direction : Roland Marquet and Bruno Lina

Bertrand Beckert (15 Oct 2010) :
“Group I Like Ribozymes : Structure, Function and Evolution”
Thesis of Strasbourg university
Direction : Benoît Masquida and Henrik Kaare Nielsen

Matthieu Frechin (8 Oct 2010) :
“Role of the mitochondrial tRNA-dependent transamidation pathway in the respiration adaptation of Saccharomyces cerevisiae”
Thesis of Strasbourg university
Direction : Daniel Kern

Maria Prokudin Ludwig (4 october 2010) :
“Study of histones H2A, H2B, H3 and H4 mRNA translation initiation”
Thesis of Strasbourg university
Direction : Gilbert Eriani

Céline Ducloux (29 Sep 2010) :
“Identification of a cellular cofactor involved in HIV-1 replication and in the resistance to reverse transcription nucleosidic inhibitors”
Thesis of Strasbourg university
Direction : Catherine Isel

Yannick-Noël Anno (24 Sep 2010) :
“Establishment of biostatistics-based bioinformatics platform for integration and analysis of genomic, epigenetic and phylogenetic data : application to hSTAF/ZNF143 transcription factor binding sites”
Thesis of Strasbourg university
Direction : Philippe Carbon and Odile Lecompte

2009
Laurence Wurth (4 Dec 2009) :
“A common assembly and maturation pathway for selenoprotein mRNPs and small non-coding RNPs”
Thesis of Strasbourg university
Direction : Christine Allmang-Cura and Alain Krol

Tania Bour (23 Oct 2009) :
“Study of tRNA binding domains in the human parasite Plasmodium falciparum”
Thesis of Strasbourg university
Direction : Magali Frugier and Richard Giegé

Clément Chevalier (20 Oct 2009) :
“Function and mecanism of action of RNAIII and new ncRNAs in Staphylococcus aureus “
Thesis of Strasbourg university
Direction : Pascale Romby

Kaouthar Dhouib (14 Oct 2009) :
“Microfluidic counter-diffusion chips for crystallization of biological macromoleculars and on chip X-ray data analysis for structure determination”
Thesis of Louis Pasteur university
Direction : Claude Sauter et Richard Giegé

Yaser Hashem (30 Sep 2009) :
“Toward a better understanding of RNA/ligands interactions : methods, tools and applications”
Thesis of Louis Pasteur university
Direction : Pascal Auffinger

Gaëlle Mercenne (18 Sep 2009) :
“Role of HIV-1 VIF protein in APOBEC3G metabolism : MRNA binding and translational inhibition”
Thesis of Strasbourg university
Direction : Roland Marquet and Jean-Christophe Paillart

Akiko Takeuchi (1 Jul 2009) :
“RNA-protein interaction in the selenoprotein synthesis machinery”
Thesis of Strasbourg university
Direction : Alain Krol and Christine Allmang-Cura

2008
Marie Messmer (19 Nov 2008) :
“Structural and functional analysis of the human mitochondrial aspartylation system and its surprising insights “
Thesis of Louis Pasteur university
Direction : Catherine Florentz

Marc Bailly (31 Oct 2008) :
“New aspects in the indirect pathways of amid aa-tRNA biosynthesis “
Thesis of Louis Pasteur university
Direction : Daniel Kern

Thomas Ludwig (17 Sep 2008) :
“Development of a bioinformatics environment dedicated to the construction of RNA architectures”
Thesis of Louis Pasteur university
Direction : Eric Westhof

2007
Yazan El Safadi (27 Nov 2007) :
“Synthesis and evaluation of modified nucleosides targeting HIV : The study of a novel mechanism of action”
Thesis of Louis Pasteur university
Direction : Roland Marquet and Valérie Vivet-Boudou

Marie-Aline Gérard (19 Nov 2007) :
“Characterization and functional analysis of novel target genes for the transcription factor hStaf/ZNF143”
Thesis of Louis Pasteur university
Direction : Philippe Carbon

Elodie Touzé (16 Nov 2007) :
“Cristallogenesis and structural studies applied to aminoacyl-tRNA synthetases”
Thesis of Louis Pasteur university
Direction : Richard Giegé

Luc Bonnefond (22 Jun 2007) :
“Human mitochondrial tyrosyl-tRNA synthetase : functional and structural idiosyncrasies and position in evolution”
Thesis of Louis Pasteur university
Direction : Richard Giegé et Joëlle Rudinger-Thirion

2006
Vincent Olieric (Nov 2006) :
“Structural study of the SBP2 protein and SECIS RNA complex”
Thesis of Louis Pasteur university
Direction : Philippe Dumas

Nouha Ben Gaied (8 Nov 2006) :
“Synthesis and evaluation of fluorescente and antiviral properties of a new class of nucleosides analogues, on the reverse transcriptase of HIV-1”
Thesis of Louis Pasteur university
Direction : Alain Burger and Roland Marquet

Mickaël Blaise (20 Oct 2006) :
“Novel functions associated to the prokaryotes aminoacylation systems”
Thesis of Louis Pasteur university
Direction : Daniel Kern

Simon Henriet (06 Oct 2006) :
“The functions of vif protein in the lifecycle of human immunodeficiency virus type 1 (HIV-1)”
Thesis of Louis Pasteur university
Direction : Roland Marquet

Mathieu Rederstorff (15 Sep 2006) :
“Toward understanding selenium and selenoprotein N functions in muscular disorders”
Thesis of Louis Pasteur university
Direction : Alain Krol and Alain Lescure

Aurélie Lescoute-Philipps (24 Feb 2006) :
“Extraction of structural constraints from sequence comparisons and RNA three-dimensional structures”
Thesis of Louis Pasteur university
Direction : Eric Westhof

2005
Andreas Werner (19 Dec 2005) :
“Structural and biophysical studies of RNase P and RNA aptamers”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Sophie Jaeger (25 november 2005) :
“Studies on the 3’ end processing and on the translation process of histone H4 mRNA”
Thesis of Louis Pasteur university
Direction : Gilbert Eriani

Maria Possedko (24 Nov 2005) :
“Function of Staphylococcus aureus RNAIII inthe regulation of virulence gene expression : Target analysis by proteomic approach”
Thesis of Louis Pasteur university
Direction : Pascale Romby and Bernard Ehresman

Aurélie Fender (18 Nov 2005) :
“Comparative analysis of tRNA / aminoacyl-tRNA synthetases couples in the yeast and human mitochondria”
Thesis of Louis Pasteur university
Direction : Catherine Florentz

Eric Huntzinger (17 Nov 2005) :
“Procaryotic regulatory RNA and virulence”
Thesis of Louis Pasteur university
Direction : Pascale Romby

Joël Didierjean (27 Oct 2005) :
“Study of a new class of human immunodeficiency virus type (HIV-1) reverse transcriptase and integrase inhibitors”
Thesis of Louis Pasteur university
Direction : Roland Marquet

Boris François (14 Oct 2005) :
“Study of complexes between aminoglycosides and bacterial decoding A site”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Michaël Ryckelynck (13 Oct 2005) :
“Functional and structural features of the regulation of a eukaryotic aminoacyl-tRNA synthetase (the case of Saccharomyces cerevisiae aspartyl-tRNA synthetase)”
Thesis of Louis Pasteur university
Direction : Richard Giegé

2004
Valérie Goldschmidt (3 Dec 2004) :
“Reverse transcription of human immunodeficiency virus typa-1 (HIV-1) : Study of various initiation complexe and mechanism of resistance toward nucleoside reverse transcriptase inhibitors (NRTIs)”
Thesis of Louis Pasteur university
Direction : Roland Marquet and Bernard Ehresmann

Jean-Sébastien Graindorge (2004) :
“Implication of the GTPase Efl1 in a cytoplasmic maturation step of 60S subunits in yeast”
Thesis of Louis Pasteur university
Direction : Franco Fasiolo

Adel Kadri (2004) :
“Physical chemical aspect of the effects of pressure on the crystallogenesis of proteins”
Thesis of Strasbourg and Sfax (Tunisie) universities
Direction : Gérard Jenner, Richard Giegé and Mohamed Damak

2003
Céline Schaeffer (2003) :
“Study of the interaction between the fragile X syndrome FMRP protein and RNA”
Thesis of Louis Pasteur university
Direction : Chantal Ehresmann

Bénédicte Sohm (17 Dec 2003) :
“Impact of pathology-related mutations within human mitochondrial tRNAs on aminoacylation properties and on the mitochondrial proteome”
Thesis of Louis Pasteur university
Direction : Catherine Florentz

Renaud Geslain (December 2003) :
“Study of the structure-function relationships, of the arginyl-tRNA synthetase and tRNAarg from Saccharomyces cerevisiae, using genetic approaches”
Thesis of Louis Pasteur university
Direction : Gilbert Eriani

2002
Alexandre Ambrogelly (Dec 2002) :
“Examples of non canonical aminoacylation systems in archaea and in pathogenic bacteria”
Thesis of Louis Pasteur university
Direction : Richard Giegè and Dieter Söll

Quentin Vicens (19 Dec 2002) :
“Structures cristallographiques de complexes entre des fragments d’acides ribonucleiques comportant le site A ribosomique et des antibiotiques de la famille des aminoglycosides”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Hervé Roy (13 Dec 2002) :
“Évolution des voies de formation d’asparagine et d’asparaginylation de l’ARNt”
Thesis of Louis Pasteur university
Direction : Daniel Kern

Mickaël Rigourd (31 Oct 2002) :
“Reverse transcription of HIV-1 : specificity of the initiation phase, inhibition by AZT and mechanism of resistance”
Thesis of Louis Pasteur university
Direction : Roland Marquet

2001
Eric Ennifar (Dec 2001) :
“Structures cristallographiques du site d’initiation de la dimérisation de l’ARN génomique du virus de l’immunodéficience humaine de type 1”
Thesis of Louis Pasteur university
Direction : Philippe Dumas and Philippe Walter

Fabrice Kolb (27 Sep 2001) :
“Rôle de deux ARN dans le contrôle de l’expression des gènes : régulations de la réplication du plasmide R1 par un ARN antisens et des gènes de virulence de Staphylococcus aureus par l’ARNIII”
Thesis of Louis Pasteur university
Direction : Chantal Ehresmann and Pascale Romby

Pierre Fechter (Feb 2001) :
“Contribution to the study of the tyrosine identity of tRNAs and tRNA-like structures”
Thesis of Louis Pasteur university
Direction : Richard Giegè

Fabrice Jossinet (13 Jan 2001) :
“Etude de la dimérisation de l’ARN génomique du virus de l’immunodéficience humaine de type 1 (HIV-1) : comparaison avec les virus HIV-2 et SIVsm”
Thesis of Louis Pasteur university
Direction : Bernard Ehresmann and Roland Marquet

2000 Wagner Celine Anne (2000) :
“bcd RNA LOCALIZATION DURING DROSOPHILA MELANOGASTER EARLY EMBRYOGENESIS : MOLECULAR MECHANISM AND FUNCTION OF RNA DIMERIZATION”
Thesis of Louis Pasteur university
Direction : Bernard Ehresmann

Valérie Gégout (14 Dec 2000) :
“A STUDY OF TRANSFERRIN RECEPTOR mRNA REGULATION BY IRP-1”
Thesis of Louis Pasteur university
Direction : Pascale Romby

Delphine Fagegaltier (22 Sep 2000) :
“Identification of new eukaryotic factors involved in selenocysteine insertion process”
Thesis of Louis Pasteur university
Direction : Alain krol

Philippe Bénas (Feb 2000) :
“Studies on HIV-1 reverse transcription initiation complex and crystal structures of two partners”
Thesis of Louis Pasteur university
Direction : Philippe Dumas

1999
Myriam Schaub (3 Dec 1999) :
“The transcriptional activator Staf : target genes and mode of binding”
Thesis of Louis Pasteur university
Direction : Alain Krol

Valérie Lehnert (8 Oct 1999) :
“Structural studies on natural and artificial ribozymes”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Benoît Masquida (18 Jun 1999) :
“Study of RNA motifs by modelling and crystallographic methods”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Mark Helm (11 Jun 1999) :
“Structural studies of human mitochondrial tRNAs related to pathologies : particular importance of post-transcriptional modifications”
Thesis of Louis Pasteur university
Direction : Richard Giegè

Claude Sauter (Jun 1999) :
“Crystallogenesis of biological macromolecules for structural studies : Application to model molecules and to components related to tRNA aminoacylation systems”
Thesis of Louis Pasteur university
Direction : Richard Giegé

1998
Philippe Brion (4 Dec 1998) :
“Group I intron folding : thermodynamic approach in vitro, functional approach in vivo”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Jean-Marc Lanchy (2 Dec 1998) :
“Initiation of HIV-1 reverse transcription : a structural and functional study”
Thesis of Louis Pasteur university
Direction : Bernard Ehresmann

Nadia Hubert (27 Nov 1998) :
“CHARACTERISATION OF FACTORS INVOLVED IN EUKARYOTIC SELENOCYSTEINE INCORPORATION”
Thesis of Louis Pasteur university
Direction : Alain Krol

Christian Massire (23 Oct 1998) :
“Development of software tools for RNA modelling. Modelling of RNase P RNA, the RNA component of eubacterial ribonuclease P”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Hubert Becker (18 Sep 1998) :
“Characterization and properties of the two aspartyl-tRNA synthetases from Thermus thermophilus. An exemple of the coexistence of ancestral and modern pathways of tRNA aminoacylation”
Thesis of Louis Pasteur university
Direction : Daniel Kern

Hervé Brulé (13 Feb 1998) :
“Human mitochondrial tRNAs and pathologies. Contribution to the understanding of molecular mechanisms responsible for tRNA dysfunction using an in vitro approach”
Thesis of Louis Pasteur university
Direction : Catherine Florentz

Marie Sissler (11 Feb 1998) :
“Contribution to the undestanding of the yeast tRNAArg aminoacylation specificity”
Thesis of Louis Pasteur university
Direction : Catherine Florentz

Laurent Ador (1998) :
“Isolation and study of functional elements of yeast aspartyl-tRNA synthetase by in vivo approaches”
Thesis of Louis Pasteur university
Direction : Jean Gangloff

1997
Robert Walczak (14 Nov 1997) :
“Decoding of selenocysteine : structure-function relationships in the SECIS RNA”
Thesis of Louis Pasteur university
Direction : Alain Krol

Marie-Hélène Mazauric (4 Jul 1997) :
“Structural and functional studies of the glycylation system from T. thermophilus”
Thesis of Louis Pasteur university
Direction : Daniel Kern

1996
Catherine Isel (12 Sep 1996) :
“Structural and functional study of the human immunodeficiency type 1 (HIV-1) initiation complex of reverse transcription”
Thesis of Louis Pasteur university
Direction : Chantal Ehresmann

Jean-Christophe Paillart (28 Jun 1996) :
“Dimerization of human immunodeficiency virus type 1 (HIV-1) genomic RNA: structural and functional studies”
Thesis of Louis Pasteur university
Direction : Chantal Ehresmann and Bernard Ehresmann

1995
Franck Martin (1995) :
“Studies of the functional conformations of aspartyl-tRNA synthetase. Molecular basis of the enzyme-substrates specific recognition”
Thesis of Louis Pasteur university
Direction : Jean Gangloff

Bruno Senger (1995) :
“Role of the anticodon in the recognition of methionine, phenylalanine and isoleucine tRNAs. Intron-dependant formation fo pseudouridines in the anticodon of yeast minor isoleucine tRNA”
Thesis of Louis Pasteur university
Direction : Franco Fasiolo

1994 Christine Allmang (1994) :
“RNA engeniering and structural studies in solution. Application to three different systems: the 16S RNA binding site of Escherichia coli protein S8, the 5S RNA of Xenopus laevis and the beet necrotic yellow vein virus RNA 3”
Thesis of Louis Pasteur university
Direction : Chantal Ehresmann

Brice Felden (18 Oct 1994) :
“Study of the structure-function relationships of tRNA-like domains of plant viral genomes”
Thesis of Louis Pasteur university
Direction : Richard Giegè and Eric Westhof

Magali Frugier (1994) :
“Manipulation of identities of transfer ribonucleic acids study of tRNAs with multiple identities and of minimalist substrates in aminoacylation reaction”
Thesis of Louis Pasteur university
Direction : Richard Giegè

Joern Pütz (1994) :
“Identity of the aminoacylation of yeast transfer RNA specific for aspartic acid”
Thesis of Louis Pasteur university
Direction : Richard Giegè

1993
Laurence Despons (1993) :
“Recognition of methionine transfer RNA by the yeast methionyl-tRNA synthetase: a functional analysis of protein and nucleic acid identity determinants”
Thesis of Louis Pasteur university
Direction : Franco Fasiolo

Luc Jaeger (25 Jun 1993) :
“Use of auto-catalytic group I introns for studying RNA three-dimensional folding”
Thesis of Louis Pasteur university
Direction : Eric Westhof and François Michel

Jean-Luc Pellequer (5 Jan 1993) :
“Structural study of protein epitopes: antigenicity predictors and affinity measurement of anti-viral monoclonal antibodies”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Alain Lescure (1993) :
“Mechanisms of transcription of U1 and U6 snRNA genes by RNA polymerases two and three”
Thesis of Louis Pasteur university
Direction : Alain Krol

1992
Chantal Rubin-Carrez (11 Dec 1992) :
“Molecular modelling and simulation of conformational and dynamics properties of ribonucleic acids: electrostatic representation and effects of the environment”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Valérie Fritsch (24 Sep 1992) :
“Molecular dynamics simulations of nucleic acids conformational properties in function of the electrostatic parameters used”
Thesis of Louis Pasteur university
Direction : Eric Westhof

Joelle Rudinger (1992) :
“Contribution to the study of the aminoacylation reaction of tRNA and tRNA-like molecules: structure/function relationships between the aspartic acid, histidine and valine systems”
Thesis of Louis Pasteur university
Direction : Richard Giegé

Christine Brunel (1992) :
“5S rRNA conformation in solution. Translational regulatory mechanism of threonyl-tRNA synthetase from Escherichia coli: an example of molecular mimetism”
Thesis of Louis Pasteur university
Direction : Eric Westhof