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2018

Goto, Akira; Okado, Kiyoshi; Martins, Nelson; Cai, Hua; Barbier, Vincent; Lamiable, Olivier; Troxler, Laurent; Santiago, Estelle; Kuhn, Lauriane; Paik, Donggi; Silverman, Neal; Holleufer, Andreas; Hartmann, Rune; Liu, Jiyong; Peng, Tao; Hoffmann, Jules A; Meignin, Carine; Daeffler, Laurent; Imler, Jean-Luc

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila Article de journal

Immunity, (49), p. 225-234, 2018.

Résumé | Liens | BibTeX | Étiquettes: antiviral immunity, C19orf12, Dicistrovirus, hoffmann, IKKβ, IMD pathway, imler, innate immunity, M3i, meignin, NF-κB, picornavirus, STING

2016

Lamiable, Olivier; Kellenberger, Christine; Kemp, Cordula; Troxler, Laurent; Pelte, Nadège; Boutros, Michael; Marques, Joao Trindade; Daeffler, Laurent; Hoffmann, Jules A; Roussel, Alain; Imler, Jean-Luc

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila Article de journal

PNAS, 113 (3), p. 698–703, 2016, ISSN: 0027-8424, 1091-6490.

Résumé | Liens | BibTeX | Étiquettes: antiviral immunity, bioinformatic, cytokine, Edin, hoffmann, imler, M3i, Sindbis Virus, virokine

Lamiable, Olivier; Arnold, Johan; da de Faria, Isaque Joao Silva; Olmo, Roenick Proveti; Bergami, Francesco; Meignin, Carine; Hoffmann, Jules A; Marques, Joao Trindade; Imler, Jean-Luc

Analysis of the Contribution of Hemocytes and Autophagy to Drosophila Antiviral Immunity Article de journal

J. Virol., 90 (11), p. 5415–5426, 2016, ISSN: 0022-538X, 1098-5514.

Liens | BibTeX | Étiquettes: antiviral immunity, Autophagy, Hemocytes, hoffmann, imler, M3i, meignin

2014

Chtarbanova, Stanislava; Lamiable, Olivier; Lee, Kwang-Zin; Galiana, Delphine; Troxler, Laurent; Meignin, Carine; Hetru, Charles; Hoffmann, Jules A; Daeffler, Laurent; Imler, Jean-Luc

Drosophila C virus systemic infection leads to intestinal obstruction Article de journal

Journal of Virology, 88 (24), p. 14057–14069, 2014, ISSN: 1098-5514.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, Dicistroviridae, Female, Gastrointestinal Tract, Gene Expression Profiling, hoffmann, imler, Intestinal Obstruction, M3i, meignin, Muscle, Nodaviridae, Sindbis Virus, Smooth, Viral Tropism

Tartey, Sarang; Matsushita, Kazufumi; Vandenbon, Alexis; Ori, Daisuke; Imamura, Tomoko; Mino, Takashi; Standley, Daron M; Hoffmann, Jules A; Reichhart, Jean-Marc; Akira, Shizuo; Takeuchi, Osamu

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex Article de journal

EMBO J., 33 (20), p. 2332–2348, 2014, ISSN: 1460-2075.

Résumé | Liens | BibTeX | Étiquettes: Adaptor Proteins, Animals, Cell Nucleus, Chromatin Assembly and Disassembly, chromatin remodeling, Chromosomal Proteins, cytokine, Cytokines, Female, Gene Expression Regulation, gene regulation, Genetic, hoffmann, Humans, Immunity, Innate, innate immunity, Knockout, Listeria monocytogenes, M3i, Macrophages, Male, Mice, Multiprotein Complexes, Non-Histone, Nuclear Proteins, Promoter Regions, Protein Binding, reichhart, Repressor Proteins, Sequence Deletion, Signal Transducing, Transcriptional Activation

Goto, Akira; Fukuyama, Hidehiro; Imler, Jean-Luc; Hoffmann, Jules A

The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response Article de journal

The Journal of Biological Chemistry, 289 (30), p. 20470–20476, 2014, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Line, Chromatin Assembly and Disassembly, Epistasis, Escherichia coli, Escherichia coli Infections, Genetic, hoffmann, imler, Immunity, Innate, M3i, NF-kappa B, Repressor Proteins, Signal Transduction, Transcription Factors

Imler, Jean-Luc; Hoffmann, Jules A

Le défi des maladies infectieuses Book Chapter

collection et prévenir demain, Ph. Cramer Guérir (Ed.): Chapitre « L’immunité innée », p. 167-174, Editions DOCIS, 2014, ISBN: 978-2-85525-390-9.

Résumé | BibTeX | Étiquettes: hoffmann, imler, innate immunity, M3i, maladies infectieuses

2013

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Article de journal

Proc. Natl. Acad. Sci. U.S.A., 110 (26), p. 10717–10722, 2013, ISSN: 1091-6490.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, hoffmann, Host-Pathogen Interactions, Humans, IMD interactome, Insect, M3i, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

Bonnay, François; Cohen-Berros, Eva; Hoffmann, Martine; Kim, Sabrina Y; Boulianne, Gabrielle L; Hoffmann, Jules A; Matt, Nicolas; Reichhart, Jean-Marc

Big bang gene modulates gut immune tolerance in Drosophila Article de journal

Proc. Natl. Acad. Sci. U.S.A., 110 (8), p. 2957–2962, 2013, ISSN: 1091-6490.

Résumé | Liens | BibTeX | Étiquettes: Animals, hoffmann, Immune Tolerance, Longevity, M3i, matt, Membrane Proteins, reichhart

2012

Lemaitre, Bruno; Nicolas, Emmanuelle; Michaut, Lydia; Reichhart, Jean-Marc; Hoffmann, Jules A

Pillars article: the dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996. 86: 973-983 Article de journal

J. Immunol., 188 (11), p. 5210–5220, 2012, ISSN: 1550-6606.

Résumé | BibTeX | Étiquettes: Animals, Antifungal Agents, Developmental, DNA-Binding Proteins, Gene Expression Regulation, history, hoffmann, M3i, Multigene Family, Mycoses, Phosphoproteins, reichhart, Toll-Like Receptors

Imler, Jean-Luc; Hoffmann, Jules A

Nucleic Acid Sensors and Antiviral Immunity Book Chapter

eds Sambhara, Fujita & T P (Ed.): Chapitre 1 : Antiviral responses in invertebrates, p. 1-18, Landes Bioscience, 2012.

BibTeX | Étiquettes: antiviral immunity, hoffmann, imler, Invertebrate, M3i

Liu, Xi; Sano, Teruyuki; Guan, Yongsheng; Nagata, Shigekazu; Hoffmann, Jules A; Fukuyama, Hidehiro

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif Article de journal

PLoS ONE, 7 (8), p. e42725, 2012, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Blotting, Conserved Sequence, Endodeoxyribonucleases, Eye Proteins, hoffmann, Immunoprecipitation, M3i, Phosphoprotein Phosphatases, Sequence Homology, Transcription Factors, Western

2011

Eleftherianos, Ioannis; Won, Sungyong; Chtarbanova, Stanislava; Squiban, Barbara; Ocorr, Karen; Bodmer, Rolf; Beutler, Bruce; Hoffmann, Jules A; Imler, Jean-Luc

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections Article de journal

Proceedings of the National Academy of Sciences of the United States of America, 108 (29), p. 12024–12029, 2011, ISSN: 1091-6490.

Résumé | Liens | BibTeX | Étiquettes: Animals, Heart, HeLa Cells, hoffmann, Humans, imler, Immunity, Immunoblotting, Inbred C57BL, Innate, KATP Channels, M3i, Mice, Nodaviridae, Pinacidil, Reverse Transcriptase Polymerase Chain Reaction, RNA Interference, Tolbutamide, Viral Load, Viremia

2009

Hetru, Charles; Hoffmann, Jules A

NF-kappaB in the immune response of Drosophila Article de journal

Cold Spring Harb Perspect Biol, 1 (6), p. a000232, 2009, ISSN: 1943-0264.

Résumé | Liens | BibTeX | Étiquettes: Animals, bacteria, Fungi, Gene Expression Regulation, hoffmann, M3i, NF-kappa B

Mishima, Yumiko; Quintin, Jessica; Aimanianda, Vishukumar; Kellenberger, Christine; Coste, Franck; Clavaud, Cecile; Hetru, Charles; Hoffmann, Jules A; Latgé, Jean-Paul; Ferrandon, Dominique; Roussel, Alain

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors Article de journal

J. Biol. Chem., 284 (42), p. 28687–28697, 2009, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, beta-Glucans, Bombyx, Carrier Proteins, Crystallography, ferrandon, Fungal Proteins, Hemolymph, hoffmann, ligands, M3i, Molecular Conformation, Mutagenesis, Polysaccharides, Protein Structure, Secondary, Tertiary, X-Ray

Fraiture, Malou; Baxter, Richard H G; Steinert, Stefanie; Chelliah, Yogarany; Frolet, Cécile; Quispe-Tintaya, Wilber; Hoffmann, Jules A; Blandin, Stéphanie A; Levashina, Elena A

Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium Article de journal

Cell Host Microbe, 5 (3), p. 273–284, 2009, ISSN: 1934-6069.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anopheles, APL1, Biological, blandin, Complement System Proteins, Hemolymph, hoffmann, Immunologic Factors, LRIM1, M3i, Models, Plasmodium, Protein Binding, Proteins, TEP1

2008

Deddouche, Safia; Matt, Nicolas; Budd, Aidan; Mueller, Stefanie; Kemp, Cordula; Galiana-Arnoux, Delphine; Dostert, Catherine; Antoniewski, Christophe; Hoffmann, Jules A; Imler, Jean-Luc

The DExD/Ħ-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Article de journal

Nature Immunology, 9 (12), p. 1425–1432, 2008, ISSN: 1529-2916.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Electrophoresis, Fat Body, Gene Expression Regulation, Genetic, Genetically Modified, hoffmann, Humans, imler, M3i, matt, Phylogeny, Polyacrylamide Gel, Reverse Transcriptase Polymerase Chain Reaction, Ribonuclease III, RNA Helicases, Sequence Homology, Transcription, Virus Diseases

Goto, Akira; Matsushita, Kazufumi; Gesellchen, Viola; Chamy, Laure El; Kuttenkeuler, David; Takeuchi, Osamu; Hoffmann, Jules A; Akira, Shizuo; Boutros, Michael; Reichhart, Jean-Marc

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice Article de journal

Nat. Immunol., 9 (1), p. 97–104, 2008, ISSN: 1529-2916.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Line, Embryo, Fibroblasts, hoffmann, Humans, Immunity, Innate, Interleukin-1beta, M3i, Mammalian, Mice, NF-kappa B, Nuclear Proteins, Proteins, reichhart, Signal Transduction, Toll-Like Receptors, transgenic, Tumor Necrosis Factor-alpha

2007

Ferrandon, Dominique; Imler, Jean-Luc; Hetru, Charles; Hoffmann, Jules A

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections Article de journal

Nat Rev Immunol, 7 , p. 862–74, 2007.

Résumé | BibTeX | Étiquettes: Animals, Bacterial Infections/*immunology/microbiology, Drosophila melanogaster/genetics/*immunology/microbiology, ferrandon, hoffmann, imler, Immunity, M3i, Mycoses/*immunology/microbiology, Natural/genetics, Signal Transduction/genetics/*immunology

Beutler, Bruce; Eidenschenk, Celine; Crozat, Karine; Imler, Jean-Luc; Takeuchi, Osamu; Hoffmann, Jules A; Akira, Shizuo

Genetic analysis of resistance to viral infection Article de journal

Nature Reviews. Immunology, 7 (10), p. 753–766, 2007, ISSN: 1474-1741.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antiviral Agents, Disease Susceptibility, Drug Resistance, Eukaryotic Cells, hoffmann, Humans, imler, Immunity, M3i, Mutation, Viral, Virus Diseases, viruses

Nehme, Nadine T; Liégeois, Samuel; Kele, Beatrix; Giammarinaro, Philippe; Pradel, Elizabeth; Hoffmann, Jules A; Ewbank, Jonathan J; Ferrandon, Dominique

A model of bacterial intestinal infections in Drosophila melanogaster Article de journal

PLoS Pathog., 3 (11), p. e173, 2007, ISSN: 1553-7374.

Résumé | Liens | BibTeX | Étiquettes: Animal, Animals, Disease Models, Electron, ferrandon, fluorescence, Hemolymph, hoffmann, Host-Pathogen Interactions, Immunohistochemistry, Intestines, M3i, Microscopy, Reverse Transcriptase Polymerase Chain Reaction, Serratia Infections, Serratia marcescens, Transmission

2006

Gottar, Marie; Gobert, Vanessa; Matskevich, Alexey A; Reichhart, Jean-Marc; Wang, Chengshu; Butt, Tariq M; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors Article de journal

Cell, 127 (7), p. 1425–1437, 2006, ISSN: 0092-8674.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibody Formation, Beauveria, Candida albicans, Carrier Proteins, Cellular, ferrandon, Glucans, hoffmann, Immunity, Immunological, M3i, Metarhizium, Models, Polysaccharides, reichhart, Serine Endopeptidases, Signal Transduction, Virulence Factors

Shiao, Shin-Hong; Whitten, Miranda M A; Zachary, Daniel; Hoffmann, Jules A; Levashina, Elena A

Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut Article de journal

PLoS Pathog., 2 (12), p. e133, 2006, ISSN: 1553-7374.

Résumé | Liens | BibTeX | Étiquettes: Actins, Animals, Anopheles, Carrier Proteins, cdc42 GTP-Binding Protein, Double-Stranded, Electron, Frizzled Receptors, Gastrointestinal Tract, hoffmann, Host-Parasite Interactions, Immunity, Innate, Insect Vectors, Intestinal Mucosa, M3i, Melanins, Microarray Analysis, Microscopy, Plasmodium berghei, Polymers, Protozoan, RNA, scanning, telomerase

Frolet, Cécile; Thoma, Martine; Blandin, Stéphanie A; Hoffmann, Jules A; Levashina, Elena A

Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei Article de journal

Immunity, 25 (4), p. 677–685, 2006, ISSN: 1074-7613.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anopheles gambiae, blandin, Gene Expression, Gene Expression Regulation, Genes, hoffmann, Immunity, Insect, M3i, NF-kappa B, Plasmodium berghei, telomerase

Galiana-Arnoux, Delphine; Dostert, Catherine; Schneemann, Anette; Hoffmann, Jules A; Imler, Jean-Luc

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila Article de journal

Nature Immunology, 7 (6), p. 590–597, 2006, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Genetically Modified, hoffmann, imler, M3i, Mutation, Nodaviridae, Ribonuclease III, RNA, RNA Helicases, RNA Interference, RNA Viruses, Viral, Viral Proteins, Virus Replication

Bischoff, Vincent; Vignal, Cécile; Duvic, Bernard; Boneca, Ivo G; Hoffmann, Jules A; Royet, Julien

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2 Article de journal

PLoS Pathog., 2 (2), p. e14, 2006, ISSN: 1553-7374.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, bacteria, Carrier Proteins, Down-Regulation, hoffmann, Larva, M3i, RNA Interference, Signal Transduction

Leclerc, Vincent; Pelte, Nadège; Chamy, Laure El; Martinelli, Cosimo; Ligoxygakis, Petros; Hoffmann, Jules A; Reichhart, Jean-Marc

Prophenoloxidase activation is not required for survival to microbial infections in Drosophila Article de journal

EMBO Rep., 7 (2), p. 231–235, 2006, ISSN: 1469-221X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Bacterial Infections, Catechol Oxidase, Enzyme Activation, Enzyme Precursors, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, hoffmann, Immunity, Innate, M3i, Mutation, reichhart, Survival Rate

2005

Kocks, Christine; Cho, Ju Hyun; Nehme, Nadine; Ulvila, Johanna; Pearson, Alan M; Meister, Marie; Strom, Charles; Conto, Stephanie L; Hetru, Charles; Stuart, Lynda M; Stehle, Thilo; Hoffmann, Jules A; Reichhart, Jean-Marc; Ferrandon, Dominique; Rämet, Mika; Ezekowitz, Alan R B

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila Article de journal

Cell, 123 (2), p. 335–346, 2005, ISSN: 0092-8674.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Amino Acid Motifs, Animals, Bacterial Infections, Cell Surface, Embryo, Escherichia coli, ferrandon, Flow Cytometry, Frameshift Mutation, Genes, Histidine, hoffmann, In Situ Hybridization, Insect, Insect Proteins, M3i, Macrophages, Membrane Proteins, messenger, Nonmammalian, Open Reading Frames, Phagocytosis, Receptors, reichhart, RNA, RNA Interference, Sequence Homology, Serratia marcescens

Irving, Phil; Ubeda, Jean-Michel; Doucet, Daniel; Troxler, Laurent; Lagueux, Marie; Zachary, Daniel; Hoffmann, Jules A; Hetru, Charles; Meister, Marie

New insights into Drosophila larval haemocyte functions through genome-wide analysis Article de journal

Cell. Microbiol., 7 (3), p. 335–350, 2005, ISSN: 1462-5814.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, Catechol Oxidase, Cell Lineage, Enzyme Precursors, Escherichia coli, Fat Body, Gene Expression Profiling, Genome, Hemocytes, hoffmann, Integrin alpha Chains, Integrins, Larva, M3i, Micrococcus luteus

Royet, Julien; Reichhart, Jean-Marc; Hoffmann, Jules A

Sensing and signaling during infection in Drosophila Article de journal

Curr. Opin. Immunol., 17 (1), p. 11–17, 2005, ISSN: 0952-7915.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, Bacterial Infections, Gene Expression Regulation, Genome, hoffmann, Immunity, Innate, M3i, reichhart, Signal Transduction

Dostert, Catherine; Jouanguy, Emmanuelle; Irving, Phil; Troxler, Laurent; Galiana-Arnoux, Delphine; Hetru, Charles; Hoffmann, Jules A; Imler, Jean-Luc

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila Article de journal

Nature Immunology, 6 (9), p. 946–953, 2005, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, DNA-Binding Proteins, Genetic, Genetically Modified, hoffmann, imler, Insect Viruses, Janus Kinase 1, M3i, Male, Oligonucleotide Array Sequence Analysis, Promoter Regions, Protein-Tyrosine Kinases, Signal Transduction, STAT1 Transcription Factor, Trans-Activators

2004

Bischoff, Vincent; Vignal, Cécile; Boneca, Ivo G; Michel, Tatiana; Hoffmann, Jules A; Royet, Julien

Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria Article de journal

Nat. Immunol., 5 (11), p. 1175–1180, 2004, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Carrier Proteins, Cell Surface, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, hoffmann, M3i, Mutation, Mycoses, Receptors, Staphylococcus aureus, Toll-Like Receptors

Levy, Francine; Rabel, David; Charlet, Maurice; Bulet, Philippe; Hoffmann, Jules A; Ehret-Sabatier, Laurence

Peptidomic and proteomic analyses of the systemic immune response of Drosophila Article de journal

Biochimie, 86 (9-10), p. 607–616, 2004, ISSN: 0300-9084.

Résumé | Liens | BibTeX | Étiquettes: Animals, hoffmann, Immunity, M3i, proteomics

Ferrandon, Dominique; Imler, Jean-Luc; Hoffmann, Jules A

Sensing infection in Drosophila: Toll and beyond Article de journal

Semin Immunol, 16 , p. 43–53, 2004, ISSN: 1044-5323.

Résumé | BibTeX | Étiquettes: Animals, Carrier Proteins/chemistry/immunology/physiology, Cell Surface/immunology/*physiology, Drosophila Proteins/chemistry/immunology/*physiology, Drosophila/genetics/*immunology/microbiology, ferrandon, Fungi/immunology, Gene Expression Regulation, Gram-Negative Bacterial Infections/immunology, Gram-Positive Bacterial Infections/immunology, hoffmann, imler, Immunological, Insect Proteins/chemistry/immunology/physiology, M3i, Models, Non-U.S. Gov't, Receptors, Signal Transduction/immunology/physiology, Support

Imler, Jean-Luc; Ferrandon, Dominique; Royet, Julien; Reichhart, Jean-Marc; Hetru, Charles; Hoffmann, Jules A

Toll-dependent and Toll-independent immune responses in Drosophila Article de journal

Journal of Endotoxin Research, 10 (4), p. 241–246, 2004, ISSN: 0968-0519.

Résumé | Liens | BibTeX | Étiquettes: Acute-Phase Proteins, Animals, Blood Proteins, Cell Surface, ferrandon, hoffmann, imler, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, reichhart, Toll-Like Receptor 5, Toll-Like Receptors, Up-Regulation

2003

Gobert, Vanessa; Gottar, Marie; Matskevich, Alexey A; Rutschmann, Sophie; Royet, Julien; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual activation of the Drosophila toll pathway by two pattern recognition receptors Article de journal

Science, 302 (5653), p. 2126–2130, 2003, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: Animals, Carrier Proteins, Cell Surface, DNA Transposable Elements, ferrandon, Gene Expression, Genes, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, hoffmann, Hypocreales, Insect, Insect Proteins, M3i, Mutation, Phenotype, Receptors, Serine Endopeptidases, Toll-Like Receptors

Thouzeau, Cécile; Maho, Yvon Le; Froget, Guillaume; Sabatier, Laurence; Bohec, Céline Le; Hoffmann, Jules A; Bulet, Philippe

Spheniscins, avian beta-defensins in preserved stomach contents of the king penguin, Aptenodytes patagonicus Article de journal

J. Biol. Chem., 278 (51), p. 51053–51058, 2003, ISSN: 0021-9258.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, bacteria, beta-Defensins, Birds, Feeding Behavior, Fungi, Gastrointestinal Contents, hoffmann, M3i, Male, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Isoforms, Sequence Alignment, Spectrometry

Hoffmann, Jules A

The immune response of Drosophila Article de journal

Nature, 426 (6962), p. 33–38, 2003, ISSN: 1476-4687.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, Immunity, Innate, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber, Alexander N R; Tauszig-Delamasure, Servane; Hoffmann, Jules A; Lelièvre, Eric; Gascan, Hugues; Ray, Keith P; Morse, Mary A; Imler, Jean-Luc; Gay, Nicholas J

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Article de journal

Nature Immunology, 4 (8), p. 794–800, 2003, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, imler, Insect Proteins, M3i, Protein Binding, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

Hetru, Charles; Troxler, Laurent; Hoffmann, Jules A

Drosophila melanogaster antimicrobial defense Article de journal

J. Infect. Dis., 187 Suppl 2 , p. S327–334, 2003, ISSN: 0022-1899.

Résumé | Liens | BibTeX | Étiquettes: Animal, Animals, Bacterial Infections, bioinformatic, hoffmann, Immunity, Innate, M3i, Mycoses, Parasitic Diseases, Peptides, Signal Transduction

Kurz, Léopold C; Chauvet, Sophie; Andrès, Emmanuel; Aurouze, Marianne; Vallet, Isabelle; Michel, Gérard P F; Uh, Mitch; Celli, Jean; Filloux, Alain; Bentzmann, Sophie De; Steinmetz, Ivo; Hoffmann, Jules A; Finlay, Brett B; Gorvel, Jean-Pierre; Ferrandon, Dominique; Ewbank, Jonathan J

Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening Article de journal

Embo J, 22 , p. 1451–60, 2003, ISBN: 0261-4189.

Résumé | Liens | BibTeX | Étiquettes: *Virulence, Animal, Caenorhabditis elegans/*microbiology, ferrandon, hoffmann, M3i, Mutation, Non-U.S. Gov't, Serratia marcescens/genetics/*pathogenicity, Support

Imler, Jean-Luc; Hoffmann, Jules A

Toll signaling: the TIReless quest for specificity Article de journal

Nature Immunology, 4 (2), p. 105–106, 2003, ISSN: 1529-2908.

Liens | BibTeX | Étiquettes: Animals, Cell Surface, Dendritic Cells, hoffmann, Humans, imler, Immunological, Interferon-beta, M3i, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

2002

Ligoxygakis, Petros; Pelte, Nadège; Ji, Chuanyi; Leclerc, Vincent; Duvic, Bernard; Belvin, Marcia; Jiang, Haobo; Hoffmann, Jules A; Reichhart, Jean-Marc

A serpin mutant links Toll activation to melanization in the host defence of Drosophila Article de journal

EMBO J., 21 (23), p. 6330–6337, 2002, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, Hemolymph, hoffmann, infection, M3i, Melanins, Receptors, reichhart, Serpins, Toll-Like Receptors

Munier, Anne-Isabelle; Doucet, Daniel; Perrodou, Emmanuel; Zachary, Daniel; Meister, Marie; Hoffmann, Jules A; Janeway, Charles A; Lagueux, Marie

PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae Article de journal

EMBO Rep., 3 (12), p. 1195–1200, 2002, ISSN: 1469-221X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibodies, Blotting, Cell Differentiation, Hemocytes, hoffmann, Immunohistochemistry, Larva, ligands, M3i, Platelet-Derived Growth Factor, Receptors, Vascular Endothelial Growth Factor, Western

Kambris, Zakaria; Hoffmann, Jules A; Imler, Jean-Luc; Capovilla, Maria

Tissue and stage-specific expression of the Tolls in Drosophila embryos Article de journal

Gene expression patterns: GEP, 2 (3-4), p. 311–317, 2002, ISSN: 1567-133X.

Résumé | BibTeX | Étiquettes: Animals, Blotting, Cell Surface, Gene Expression Profiling, hoffmann, imler, Larva, M3i, Multigene Family, Northern, Receptors, Toll-Like Receptors

Duvic, Bernard; Hoffmann, Jules A; Meister, Marie; Royet, Julien

Notch signaling controls lineage specification during Drosophila larval hematopoiesis Article de journal

Curr. Biol., 12 (22), p. 1923–1927, 2002, ISSN: 0960-9822.

Résumé | BibTeX | Étiquettes: Animals, Cell Differentiation, Hematopoiesis, hoffmann, Larva, Lymphoid Tissue, M3i, Membrane Proteins, Notch, Receptors, Signal Transduction

Naitza, Silvia; Rossé, Carine; Kappler, Christine; Georgel, Philippe; Belvin, Marcia; Gubb, David; Camonis, Jacques; Hoffmann, Jules A; Reichhart, Jean-Marc

The Drosophila immune defense against gram-negative infection requires the death protein dFADD Article de journal

Immunity, 17 (5), p. 575–581, 2002, ISSN: 1074-7613.

Résumé | BibTeX | Étiquettes: Adaptor Proteins, Animals, Carrier Proteins, Fas-Associated Death Domain Protein, Gene Expression Regulation, Gram-Negative Bacterial Infections, hoffmann, Immunity, M3i, reichhart, Signal Transducing, Signal Transduction

Christophides, George K; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie A; Blass, Claudia; Brey, Paul T; Collins, Frank H; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T; Hoffmann, Jules A; Kanzok, Stefan M; Letunic, Ivica; Levashina, Elena A; Loukeris, Thanasis G; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F; Müller, Hans-Michael; Osta, Mike A; Paskewitz, Susan M; Reichhart, Jean-Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D; Vlachou, Dina; Volz, Jennifer; von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C

Immunity-related genes and gene families in Anopheles gambiae Article de journal

Science, 298 (5591), p. 159–165, 2002, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: Alternative Splicing, Animals, Anopheles, Apoptosis, bacteria, bioinformatic, blandin, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, hoffmann, Immunity, Innate, Insect, Insect Proteins, M3i, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, reichhart, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

Ligoxygakis, Petros; Pelte, Nadège; Hoffmann, Jules A; Reichhart, Jean-Marc

Activation of Drosophila Toll during fungal infection by a blood serine protease Article de journal

Science, 297 (5578), p. 114–116, 2002, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, Chromosome Mapping, Escherichia coli, Female, Gene Expression Regulation, Genes, Gram-Positive Cocci, Hemolymph, hoffmann, Hypocreales, Insect, Insect Proteins, M3i, Male, Mutation, Protein Sorting Signals, Protein Structure, Receptors, reichhart, Serine Endopeptidases, Tertiary, Toll-Like Receptors

Gottar, Marie; Gobert, Vanessa; Michel, Tatiana; Belvin, Marcia; Duyk, Geoffrey; Hoffmann, Jules A; Ferrandon, Dominique; Royet, Julien

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein Article de journal

Nature, 416 , p. 640–644, 2002, ISBN: 0028-0836.

Résumé | Liens | BibTeX | Étiquettes: Animal, Anti-Infective Agents/metabolism, Carrier Proteins/biosynthesis/genetics/*immunology, Drosophila melanogaster/genetics/*immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epistasis, Female, ferrandon, Genes, Genetic, Genetic Predisposition to Disease, Gram-Negative Bacteria/*immunology/physiology, hoffmann, Human, Insect/genetics, M3i, Messenger/genetics/metabolism, Mutation, Non-U.S. Gov't, P.H.S., Phenotype, RNA, Signal Transduction, Support, Survival Rate, Transgenes/genetics, U.S. Gov't

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