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2014

Lamiable, Olivier; Imler, Jean-Luc

Induced antiviral innate immunity in Drosophila Article de journal

Current Opinion in Microbiology, 20 , p. 62–68, 2014, ISSN: 1879-0364.

Résumé | Liens | BibTeX | Étiquettes: Animals, Gene Expression Regulation, Host-Pathogen Interactions, imler, Immunity, Innate, M3i, RNA Viruses, Signal Transduction

Goto, Akira; Fukuyama, Hidehiro; Imler, Jean-Luc; Hoffmann, Jules A

The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response Article de journal

The Journal of Biological Chemistry, 289 (30), p. 20470–20476, 2014, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Line, Chromatin Assembly and Disassembly, Epistasis, Escherichia coli, Escherichia coli Infections, Genetic, hoffmann, imler, Immunity, Innate, M3i, NF-kappa B, Repressor Proteins, Signal Transduction, Transcription Factors

Imler, Jean-Luc

Overview of Drosophila immunity: a historical perspective Article de journal

Developmental and Comparative Immunology, 42 (1), p. 3–15, 2014, ISSN: 1879-0089.

Résumé | Liens | BibTeX | Étiquettes: Allergy and Immunology, Animal, Animals, Antimicrobial Cationic Peptides, Antimicrobial peptides, history, Humans, IMD pathway, imler, Immunity, Innate, innate immunity, M3i, Models, Pattern recognition receptors, Signal Transduction, Toll-Like Receptors

2013

Fukuyama, Hidehiro; Verdier, Yann; Guan, Yongsheng; Makino-Okamura, Chieko; Shilova, Victoria; Liu, Xi; Maksoud, Elie; Matsubayashi, Jun; Haddad, Iman; Spirohn, Kerstin; Ono, Kenichiro; Hetru, Charles; Rossier, Jean; Ideker, Trey; Boutros, Michael; Vinh, Joëlle; Hoffmann, Jules A

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge Article de journal

Proc. Natl. Acad. Sci. U.S.A., 110 (26), p. 10717–10722, 2013, ISSN: 1091-6490.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Chromatin Assembly and Disassembly, Escherichia coli, functional proteomics, Genes, Genetically Modified, Histone Acetyltransferases, hoffmann, Host-Pathogen Interactions, Humans, IMD interactome, Insect, M3i, Models, Molecular, Protein Interaction Maps, Sequence Homology, Signal Transduction, small ubiquitin-like modifier

Quintin, Jessica; Asmar, Joelle; Matskevich, Alexey A; Lafarge, Marie-Céline; Ferrandon, Dominique

The Drosophila Toll pathway controls but does not clear Candida glabrata infections Article de journal

J. Immunol., 190 (6), p. 2818–2827, 2013, ISSN: 1550-6606.

Résumé | Liens | BibTeX | Étiquettes: Adaptor Proteins, Animal, Animals, Antigens, Candida glabrata, Candidiasis, Cells, Cultured, Differentiation, Disease Models, ferrandon, Immunologic, M3i, Phagocytosis, Receptors, Signal Transducing, Signal Transduction, Toll-Like Receptors, Virulence

2012

Coste, Franck; Kemp, Cordula; Bobezeau, Vanessa; Hetru, Charles; Kellenberger, Christine; Imler, Jean-Luc; Roussel, Alain

Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster Article de journal

PloS One, 7 (3), p. e33416, 2012, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Animals, Aphids, Crystallography, imler, Janus Kinases, M3i, Protein Folding, Protein Structure, Signal Transduction, STAT Transcription Factors, Tertiary, Transcription Factors, X-Ray

Deleury, Emeline; Dubreuil, Géraldine; Elangovan, Namasivayam; Wajnberg, Eric; Reichhart, Jean-Marc; Gourbal, Benjamin; Duval, David; Baron, Olga Lucia; Gouzy, Jérôme; Coustau, Christine

Specific versus non-specific immune responses in an invertebrate species evidenced by a comparative de novo sequencing study Article de journal

PLoS ONE, 7 (3), p. e32512, 2012, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biomphalaria, Calmodulin, Cluster Analysis, Complementary, DNA, Expressed Sequence Tags, Ferritins, Gene Expression Profiling, Gene Expression Regulation, High-Throughput Nucleotide Sequencing, Immunity, Innate, M3i, messenger, Pattern Recognition, Phylogeny, Receptors, reichhart, RNA, Signal Transduction, Zinc Fingers

Meister, Marie; Ferrandon, Dominique

Immune cell transdifferentiation: a complex crosstalk between circulating immune cells and the haematopoietic niche Article de journal

EMBO Rep., 13 (1), p. 3–4, 2012, ISSN: 1469-3178.

Liens | BibTeX | Étiquettes: Animals, Cell Communication, Cell Transdifferentiation, ferrandon, Hematopoietic Stem Cells, Humans, Immune System, M3i, Signal Transduction, Stem Cell Niche

2011

Boyer, Laurent; Magoc, Lorin; Dejardin, Stephanie; Cappillino, Michael; Paquette, Nicholas; Hinault, Charlotte; Charriere, Guillaume M; Ip, Eddie W K; Fracchia, Shannon; Hennessy, Elizabeth; Erturk-Hasdemir, Deniz; Reichhart, Jean-Marc; Silverman, Neal; Lacy-Hulbert, Adam; Stuart, Lynda M

Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway Article de journal

Immunity, 35 (4), p. 536–549, 2011, ISSN: 1097-4180.

Résumé | Liens | BibTeX | Étiquettes: Adaptor Proteins, Enzyme Activation, HEK293 Cells, Humans, M3i, rac GTP-Binding Proteins, Receptor-Interacting Protein Serine-Threonine Kinases, reichhart, Signal Transducing, Signal Transduction

Kellenberger, Christine; Leone, Philippe; Coquet, Laurent; Jouenne, Thierry; Reichhart, Jean-Marc; Roussel, Alain

Structure-function analysis of grass clip serine protease involved in Drosophila Toll pathway activation Article de journal

J. Biol. Chem., 286 (14), p. 12300–12307, 2011, ISSN: 1083-351X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Catalytic Domain, Cell Line, M3i, reichhart, Serine Proteases, Signal Transduction, Structure-Activity Relationship, Toll-Like Receptors

Reichhart, Jean-Marc; Gubb, David; Leclerc, Vincent

The Drosophila serpins: multiple functions in immunity and morphogenesis Article de journal

Meth. Enzymol., 499 , p. 205–225, 2011, ISSN: 1557-7988.

Résumé | Liens | BibTeX | Étiquettes: Animals, Immunity, Innate, M3i, Morphogenesis, reichhart, Serpins, Signal Transduction

Nehme, Nadine T; Quintin, Jessica; Cho, Ju Hyun; Lee, Janice; Lafarge, Marie-Céline; Kocks, Christine; Ferrandon, Dominique

Relative roles of the cellular and humoral responses in the Drosophila host defense against three gram-positive bacterial infections Article de journal

PLoS ONE, 6 (3), p. e14743, 2011, ISSN: 1932-6203.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, Carrier Proteins, Cell Surface, Cellular, Enterococcus faecalis, ferrandon, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Host-Pathogen Interactions, Humoral, Immunity, Innate, M3i, Micrococcus luteus, Opsonin Proteins, Phagocytosis, Receptors, Signal Transduction, Solubility, Staphylococcus aureus

2010

Paquette, Nicholas; Broemer, Meike; Aggarwal, Kamna; Chen, Li; Husson, Marie; Ertürk-Hasdemir, Deniz; Reichhart, Jean-Marc; Meier, Pascal; Silverman, Neal

Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling Article de journal

Mol. Cell, 37 (2), p. 172–182, 2010, ISSN: 1097-4164.

Résumé | Liens | BibTeX | Étiquettes: Alleles, Amino Acid Motifs, Animals, Biological, Caspases, Inhibitor of Apoptosis Proteins, M3i, MAP Kinase Kinase Kinases, Models, NF-kappa B, reichhart, Sequence Alignment, Signal Transduction, Ubiquitin-Protein Ligases, Ubiquitination

2009

Cronin, Shane J F; Nehme, Nadine T; Limmer, Stefanie; Liegeois, Samuel; Pospisilik, Andrew J; Schramek, Daniel; Leibbrandt, Andreas; de Simoes, Ricardo Matos; Gruber, Susanne; Puc, Urszula; Ebersberger, Ingo; Zoranovic, Tamara; Neely, Gregory G; von Haeseler, Arndt; Ferrandon, Dominique; Penninger, Josef M

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Article de journal

Science, 325 (5938), p. 340–343, 2009, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: *Genome, *RNA Interference, Animal, Animals, Cell Proliferation, Drosophila melanogaster/*genetics/immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epithelial Cells, Epithelial Cells/cytology/physiology, ferrandon, Genetically Modified, Genome, Hemocytes, Hemocytes/immunology/metabolism/microbiology, Homeostasis, Immunity, Innate, Innate/*genetics, Insect, Intestinal Mucosa, Intestinal Mucosa/cytology/immunology/metabolism/microbiology, Janus Kinases, Janus Kinases/genetics/metabolism, M3i, Models, RNA Interference, Serratia Infections, Serratia Infections/genetics/*immunology/microbiology, Serratia marcescens, Serratia marcescens/*immunology/physiology, Signal Transduction, STAT Transcription Factors, STAT Transcription Factors/genetics/metabolism, Stem Cells, Stem Cells/cytology/physiology

2008

Chamy, Laure El; Leclerc, Vincent; Caldelari, Isabelle; Reichhart, Jean-Marc

Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll Article de journal

Nat. Immunol., 9 (10), p. 1165–1170, 2008, ISSN: 1529-2916.

Résumé | Liens | BibTeX | Étiquettes: Animals, Fungi, Genetically Modified, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, In Situ Hybridization, M3i, Mycoses, Pattern Recognition, Peptide Hydrolases, Receptors, reichhart, Serine Endopeptidases, Signal Transduction, Toll-Like Receptors

Goto, Akira; Matsushita, Kazufumi; Gesellchen, Viola; Chamy, Laure El; Kuttenkeuler, David; Takeuchi, Osamu; Hoffmann, Jules A; Akira, Shizuo; Boutros, Michael; Reichhart, Jean-Marc

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice Article de journal

Nat. Immunol., 9 (1), p. 97–104, 2008, ISSN: 1529-2916.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Line, Embryo, Fibroblasts, hoffmann, Humans, Immunity, Innate, Interleukin-1beta, M3i, Mammalian, Mice, NF-kappa B, Nuclear Proteins, Proteins, reichhart, Signal Transduction, Toll-Like Receptors, transgenic, Tumor Necrosis Factor-alpha

2007

Weber, Alexander N R; Gangloff, Monique; Moncrieffe, Martin C; Hyvert, Yann; Imler, Jean-Luc; Gay, Nicholas J

Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand Article de journal

The Journal of Biological Chemistry, 282 (18), p. 13522–13531, 2007, ISSN: 0021-9258.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cytokines, dimerization, imler, ligands, M3i, Post-Translational, Protein Binding, Protein Processing, Protein Structure, Signal Transduction, Tertiary, Toll-Like Receptors

2006

Gottar, Marie; Gobert, Vanessa; Matskevich, Alexey A; Reichhart, Jean-Marc; Wang, Chengshu; Butt, Tariq M; Belvin, Marcia; Hoffmann, Jules A; Ferrandon, Dominique

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors Article de journal

Cell, 127 (7), p. 1425–1437, 2006, ISSN: 0092-8674.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antibody Formation, Beauveria, Candida albicans, Carrier Proteins, Cellular, ferrandon, Glucans, hoffmann, Immunity, Immunological, M3i, Metarhizium, Models, Polysaccharides, reichhart, Serine Endopeptidases, Signal Transduction, Virulence Factors

Evans, J D; Aronstein, K; Chen, Y P; Hetru, Charles; Imler, Jean-Luc; Jiang, H; Kanost, M; Thompson, G J; Zou, Z; Hultmark, D

Immune pathways and defence mechanisms in honey bees Apis mellifera Article de journal

Insect Molecular Biology, 15 (5), p. 645–656, 2006, ISSN: 0962-1075.

Résumé | Liens | BibTeX | Étiquettes: Animals, Bees, Carrier Proteins, Genome, imler, Immunity, Insect, Janus Kinases, M3i, Multigene Family, Serine Endopeptidases, Signal Transduction, STAT Transcription Factors, Toll-Like Receptors

Bischoff, Vincent; Vignal, Cécile; Duvic, Bernard; Boneca, Ivo G; Hoffmann, Jules A; Royet, Julien

Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2 Article de journal

PLoS Pathog., 2 (2), p. e14, 2006, ISSN: 1553-7374.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, bacteria, Carrier Proteins, Down-Regulation, hoffmann, Larva, M3i, RNA Interference, Signal Transduction

Pelte, Nadège; Robertson, Andrew S; Zou, Zhen; Belorgey, Didier; Dafforn, Timothy R; Jiang, Haobo; Lomas, David; Reichhart, Jean-Marc; Gubb, David

Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic Article de journal

Insect Biochem. Mol. Biol., 36 (1), p. 37–46, 2006, ISSN: 0965-1748.

Résumé | Liens | BibTeX | Étiquettes: Animals, Gene Expression Regulation, M3i, Protein Conformation, reichhart, Serpins, Signal Transduction

Galiana-Arnoux, Delphine; Imler, Jean-Luc

Toll-like receptors and innate antiviral immunity Article de journal

Tissue Antigens, 67 (4), p. 267–276, 2006, ISSN: 0001-2815.

Résumé | Liens | BibTeX | Étiquettes: Animals, Humans, imler, Immunity, Innate, M3i, Signal Transduction, Toll-Like Receptors, Virus Diseases

2005

Royet, Julien; Reichhart, Jean-Marc; Hoffmann, Jules A

Sensing and signaling during infection in Drosophila Article de journal

Curr. Opin. Immunol., 17 (1), p. 11–17, 2005, ISSN: 0952-7915.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, Bacterial Infections, Gene Expression Regulation, Genome, hoffmann, Immunity, Innate, M3i, reichhart, Signal Transduction

Dostert, Catherine; Jouanguy, Emmanuelle; Irving, Phil; Troxler, Laurent; Galiana-Arnoux, Delphine; Hetru, Charles; Hoffmann, Jules A; Imler, Jean-Luc

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila Article de journal

Nature Immunology, 6 (9), p. 946–953, 2005, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, DNA-Binding Proteins, Genetic, Genetically Modified, hoffmann, imler, Insect Viruses, Janus Kinase 1, M3i, Male, Oligonucleotide Array Sequence Analysis, Promoter Regions, Protein-Tyrosine Kinases, Signal Transduction, STAT1 Transcription Factor, Trans-Activators

Martinelli, Cosimo; Reichhart, Jean-Marc

Evolution and integration of innate immune systems from fruit flies to man: lessons and questions Article de journal

J. Endotoxin Res., 11 (4), p. 243–248, 2005, ISSN: 0968-0519.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological Evolution, Cell Surface, Forecasting, Humans, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber, Alexander N R; Moncrieffe, Martin C; Gangloff, Monique; Imler, Jean-Luc; Gay, Nicholas J

Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway Article de journal

The Journal of Biological Chemistry, 280 (24), p. 22793–22799, 2005, ISSN: 0021-9258.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Biophysical Phenomena, Biophysics, Body Patterning, Calorimetry, Cell Line, Cell Surface, Cross-Linking Reagents, Cytokines, dimerization, Electrophoresis, Humans, imler, ligands, Luciferases, M3i, Membrane Glycoproteins, Polyacrylamide Gel, Protein Binding, Protein Structure, Receptors, Recombinant Proteins, Sequence Homology, Signal Transduction, Tertiary, Time Factors, Toll-Like Receptors, Ultracentrifugation

Imler, Jean-Luc; Bulet, Philippe

Antimicrobial peptides in Drosophila: structures, activities and gene regulation Article de journal

Chemical Immunology and Allergy, 86 , p. 1–21, 2005, ISSN: 1660-2242.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antimicrobial Cationic Peptides, Defensins, Gene Expression Regulation, Genes, Glycopeptides, imler, Immunity, Innate, Insect, Insect Proteins, M3i, Molecular Structure, Signal Transduction

2004

Irving, Phil; Troxler, Laurent; Hetru, Charles

Is innate enough? The innate immune response in Drosophila Article de journal

C. R. Biol., 327 (6), p. 557–570, 2004, ISSN: 1631-0691.

Résumé | BibTeX | Étiquettes: Animals, bioinformatic, Immunity, Innate, M3i, Signal Transduction

Leclerc, Vincent; Reichhart, Jean-Marc

The immune response of Drosophila melanogaster Article de journal

Immunol. Rev., 198 , p. 59–71, 2004, ISSN: 0105-2896.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, Immunity, Immunological, Innate, M3i, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

Imler, Jean-Luc; Zheng, Liangbiao

Biology of Toll receptors: lessons from insects and mammals Article de journal

Journal of Leukocyte Biology, 75 (1), p. 18–26, 2004, ISSN: 0741-5400.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anopheles, Cell Surface, Humans, imler, M3i, Membrane Glycoproteins, Mice, Phylogeny, Plant Physiological Phenomena, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

2003

Ligoxygakis, Petros; Roth, Siegfried; Reichhart, Jean-Marc

A serpin regulates dorsal-ventral axis formation in the Drosophila embryo Article de journal

Curr. Biol., 13 (23), p. 2097–2102, 2003, ISSN: 0960-9822.

Résumé | BibTeX | Étiquettes: Animals, Body Patterning, Cell Surface, Crosses, Female, Genetic, Immunohistochemistry, M3i, Microinjections, Receptors, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors

Royet, Julien; Reichhart, Jean-Marc

Detection of peptidoglycans by NOD proteins Article de journal

Trends Cell Biol., 13 (12), p. 610–614, 2003, ISSN: 0962-8924.

Résumé | BibTeX | Étiquettes: Adaptor Proteins, Apoptosis, Carrier Proteins, Gram-Positive Bacteria, Humans, Immunity, Immunologic, Innate, M3i, Nod1 Signaling Adaptor Protein, Oligopeptides, peptidoglycan, Receptors, reichhart, Signal Transducing, Signal Transduction

Goto, Akira; Blandin, Stéphanie A; Royet, Julien; Reichhart, Jean-Marc; Levashina, Elena A

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies Article de journal

Nucleic Acids Res., 31 (22), p. 6619–6623, 2003, ISSN: 1362-4962.

Résumé | BibTeX | Étiquettes: Animals, blandin, Cell Surface, Double-Stranded, Epistasis, Female, Genetic, Green Fluorescent Proteins, Homeodomain Proteins, Luminescent Proteins, M3i, Phenotype, Receptors, reichhart, RNA, RNA Interference, Serpins, Signal Transduction, Time Factors, Toll-Like Receptors, Transcription Factors

Hoffmann, Jules A

The immune response of Drosophila Article de journal

Nature, 426 (6962), p. 33–38, 2003, ISSN: 1476-4687.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, Immunity, Innate, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptor 5, Toll-Like Receptors

Weber, Alexander N R; Tauszig-Delamasure, Servane; Hoffmann, Jules A; Lelièvre, Eric; Gascan, Hugues; Ray, Keith P; Morse, Mary A; Imler, Jean-Luc; Gay, Nicholas J

Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling Article de journal

Nature Immunology, 4 (8), p. 794–800, 2003, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Cell Surface, hoffmann, imler, Insect Proteins, M3i, Protein Binding, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

Hetru, Charles; Troxler, Laurent; Hoffmann, Jules A

Drosophila melanogaster antimicrobial defense Article de journal

J. Infect. Dis., 187 Suppl 2 , p. S327–334, 2003, ISSN: 0022-1899.

Résumé | Liens | BibTeX | Étiquettes: Animal, Animals, Bacterial Infections, bioinformatic, hoffmann, Immunity, Innate, M3i, Mycoses, Parasitic Diseases, Peptides, Signal Transduction

Luna, C; Hoa, N T; Zhang, J; Kanzok, S M; Brown, S E; Imler, Jean-Luc; Knudson, D L; Zheng, L

Characterization of three Toll-like genes from mosquito Aedes aegypti Article de journal

Insect Molecular Biology, 12 (1), p. 67–74, 2003, ISSN: 0962-1075.

Résumé | BibTeX | Étiquettes: Aedes, Animals, Base Sequence, Cell Surface, Chimera, Cloning, Developmental, Female, Gene Expression Regulation, Genetic, imler, Insect Proteins, M3i, Male, messenger, Models, Molecular, Mutagenesis, Promoter Regions, Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sequence Alignment, Signal Transduction, Site-Directed, Transfection

Imler, Jean-Luc; Hoffmann, Jules A

Toll signaling: the TIReless quest for specificity Article de journal

Nature Immunology, 4 (2), p. 105–106, 2003, ISSN: 1529-2908.

Liens | BibTeX | Étiquettes: Animals, Cell Surface, Dendritic Cells, hoffmann, Humans, imler, Immunological, Interferon-beta, M3i, Membrane Glycoproteins, Mice, Models, Protein Structure, Receptors, Signal Transduction, Tertiary, Toll-Like Receptors

2002

Duvic, Bernard; Hoffmann, Jules A; Meister, Marie; Royet, Julien

Notch signaling controls lineage specification during Drosophila larval hematopoiesis Article de journal

Curr. Biol., 12 (22), p. 1923–1927, 2002, ISSN: 0960-9822.

Résumé | BibTeX | Étiquettes: Animals, Cell Differentiation, Hematopoiesis, hoffmann, Larva, Lymphoid Tissue, M3i, Membrane Proteins, Notch, Receptors, Signal Transduction

Naitza, Silvia; Rossé, Carine; Kappler, Christine; Georgel, Philippe; Belvin, Marcia; Gubb, David; Camonis, Jacques; Hoffmann, Jules A; Reichhart, Jean-Marc

The Drosophila immune defense against gram-negative infection requires the death protein dFADD Article de journal

Immunity, 17 (5), p. 575–581, 2002, ISSN: 1074-7613.

Résumé | BibTeX | Étiquettes: Adaptor Proteins, Animals, Carrier Proteins, Fas-Associated Death Domain Protein, Gene Expression Regulation, Gram-Negative Bacterial Infections, hoffmann, Immunity, M3i, reichhart, Signal Transducing, Signal Transduction

Christophides, George K; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie A; Blass, Claudia; Brey, Paul T; Collins, Frank H; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T; Hoffmann, Jules A; Kanzok, Stefan M; Letunic, Ivica; Levashina, Elena A; Loukeris, Thanasis G; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F; Müller, Hans-Michael; Osta, Mike A; Paskewitz, Susan M; Reichhart, Jean-Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D; Vlachou, Dina; Volz, Jennifer; von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C

Immunity-related genes and gene families in Anopheles gambiae Article de journal

Science, 298 (5591), p. 159–165, 2002, ISSN: 1095-9203.

Résumé | Liens | BibTeX | Étiquettes: Alternative Splicing, Animals, Anopheles, Apoptosis, bacteria, bioinformatic, blandin, Catechol Oxidase, Computational Biology, Enzyme Precursors, Gene Expression Regulation, Genes, Genetic, Genome, hoffmann, Immunity, Innate, Insect, Insect Proteins, M3i, Multigene Family, Peptides, Phylogeny, Plasmodium, Protein Structure, reichhart, Selection, Serine Endopeptidases, Serpins, Signal Transduction, Tertiary

Gottar, Marie; Gobert, Vanessa; Michel, Tatiana; Belvin, Marcia; Duyk, Geoffrey; Hoffmann, Jules A; Ferrandon, Dominique; Royet, Julien

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein Article de journal

Nature, 416 , p. 640–644, 2002, ISBN: 0028-0836.

Résumé | Liens | BibTeX | Étiquettes: Animal, Anti-Infective Agents/metabolism, Carrier Proteins/biosynthesis/genetics/*immunology, Drosophila melanogaster/genetics/*immunology/*microbiology, Drosophila Proteins/genetics/metabolism, Epistasis, Female, ferrandon, Genes, Genetic, Genetic Predisposition to Disease, Gram-Negative Bacteria/*immunology/physiology, hoffmann, Human, Insect/genetics, M3i, Messenger/genetics/metabolism, Mutation, Non-U.S. Gov't, P.H.S., Phenotype, RNA, Signal Transduction, Support, Survival Rate, Transgenes/genetics, U.S. Gov't

Hoffmann, Jules A; Reichhart, Jean-Marc

Drosophila innate immunity: an evolutionary perspective Article de journal

Nat. Immunol., 3 (2), p. 121–126, 2002, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Biological Evolution, Cell Surface, hoffmann, Immunity, Immunological, Innate, M3i, Membrane Glycoproteins, Models, Receptors, reichhart, Signal Transduction, Toll-Like Receptors

Imler, Jean-Luc; Hoffmann, Jules A

Toll receptors in Drosophila: a family of molecules regulating development and immunity Article de journal

Current Topics in Microbiology and Immunology, 270 , p. 63–79, 2002, ISSN: 0070-217X.

Résumé | BibTeX | Étiquettes: Animals, Cell Surface, Genetic, Gram-Negative Bacteria, hoffmann, imler, M3i, Receptors, Signal Transduction, Toll-Like Receptors, Transcription

2001

Irving, Phil; Troxler, Laurent; Heuer, Timothy S; Belvin, Marcia; Kopczynski, Casey; Reichhart, Jean-Marc; Hoffmann, Jules A; Hetru, Charles

A genome-wide analysis of immune responses in Drosophila Article de journal

Proc. Natl. Acad. Sci. U.S.A., 98 (26), p. 15119–15124, 2001, ISSN: 0027-8424.

Résumé | Liens | BibTeX | Étiquettes: Animals, bioinformatic, Gene Expression Regulation, Genome, Gram-Negative Bacteria, hoffmann, M3i, Male, Oligonucleotide Array Sequence Analysis, reichhart, Signal Transduction

2000

Rutschmann, Sophie; Jung, Alain C; Zhou, R; Silverman, N; Hoffmann, Jules A; Ferrandon, Dominique

Role of Drosophila IKK gamma in a toll-independent antibacterial immune response Article de journal

Nat. Immunol., 1 (4), p. 342–347, 2000, ISSN: 1529-2908.

Résumé | Liens | BibTeX | Étiquettes: Animals, Antigens, Bacterial, Cell Surface, ferrandon, Gene Expression Regulation, hoffmann, I-kappa B Kinase, Immunity, Innate, Insect Proteins, M3i, Membrane Glycoproteins, Protein-Serine-Threonine Kinases, Receptors, Signal Transduction, Toll-Like Receptors, Transcription Factors

Imler, Jean-Luc; Hoffmann, Jules A

Signaling mechanisms in the antimicrobial host defense of Drosophila Article de journal

Current Opinion in Microbiology, 3 (1), p. 16–22, 2000, ISSN: 1369-5274.

Résumé | BibTeX | Étiquettes: Animals, Anti-Infective Agents, Cell Surface, Gene Expression Regulation, Genes, hoffmann, imler, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Receptors, Signal Transduction, Toll-Like Receptors

Imler, Jean-Luc; Tauszig, Servane; Jouanguy, Emmanuelle; Forestier, C; Hoffmann, Jules A

LPS-induced immune response in Drosophila Article de journal

Journal of Endotoxin Research, 6 (6), p. 459–462, 2000, ISSN: 0968-0519.

Résumé | BibTeX | Étiquettes: Animals, Biological, Cell Line, Cell Surface, Defensins, Genes, Genetic, hoffmann, imler, Insect, Insect Proteins, Lipopolysaccharides, M3i, Membrane Glycoproteins, Models, Mutation, Promoter Regions, Receptors, Signal Transduction, Toll-Like Receptors

Imler, Jean-Luc; Hoffmann, Jules A

Toll and Toll-like proteins: an ancient family of receptors signaling infection Article de journal

Reviews in Immunogenetics, 2 (3), p. 294–304, 2000, ISSN: 1398-1714.

Résumé | BibTeX | Étiquettes: Adaptor Proteins, Animals, Antigens, Autoantigens, CD14, Cell Adhesion Molecules, Cell Surface, Differentiation, DNA-Binding Proteins, Gene Expression Regulation, hoffmann, I-kappa B Proteins, imler, Immunity, Immunologic, infection, Innate, Insect Proteins, Interleukin-1 Receptor-Associated Kinases, Knockout, Larva, Lipopolysaccharides, M3i, Mammals, MAP Kinase Signaling System, Membrane Glycoproteins, Membrane Proteins, Mice, Multigene Family, Myeloid Differentiation Factor 88, NF-kappa B, peptidoglycan, Phosphorylation, Post-Translational, Protein Kinases, Protein Processing, Protein Structure, Receptors, Recombinant Fusion Proteins, Signal Transducing, Signal Transduction, Teichoic Acids, Tertiary, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptor 6, Toll-Like Receptor 9, Toll-Like Receptors, Ubiquitins

1999

Levashina, Elena A; Langley, E; Green, C; Gubb, David; Ashburner, M; Hoffmann, Jules A; Reichhart, Jean-Marc

Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila Article de journal

Science, 285 (5435), p. 1917–1919, 1999, ISSN: 0036-8075.

Résumé | BibTeX | Étiquettes: Animals, Antifungal Agents, Antimicrobial Cationic Peptides, Body Patterning, Cell Surface, Escherichia coli, Genes, Hemolymph, hoffmann, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutagenesis, Peptides, Receptors, Recombinant Fusion Proteins, reichhart, Serine Proteinase Inhibitors, Serpins, Signal Transduction, Toll-Like Receptors, Up-Regulation

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