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2002

Ligoxygakis, Petros; Bulet, Philippe; Reichhart, Jean-Marc

Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila Article de journal

EMBO Rep., 3 (7), p. 666–673, 2002, ISSN: 1469-221X.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Cell Adhesion Molecules, Fat Body, Gene Expression Regulation, Genes, Immunohistochemistry, Immunologic, Insect, Insect Proteins, Larva, M3i, Mass, Matrix-Assisted Laser Desorption-Ionization, Membrane Proteins, Receptors, reichhart, Reporter, Spectrometry, Transgenes

2001

Michel, T; Reichhart, Jean-Marc; Hoffmann, Jules A; Royet, Julien

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein Article de journal

Nature, 414 (6865), p. 756–759, 2001, ISSN: 0028-0836.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Anti-Infective Agents, Bacillus thuringiensis, Carrier Proteins, Cell Surface, Chromosome Mapping, Enterococcus faecalis, Fungi, Genes, Gram-Positive Bacteria, Hemolymph, hoffmann, Humans, Insect, Insect Proteins, M3i, Membrane Glycoproteins, Micrococcus luteus, Mutation, Receptors, reichhart, Sequence Homology, Toll-Like Receptors

Vizioli, J; Bulet, Philippe; Hoffmann, Jules A; Kafatos, Fotis C; Müller, H M; Dimopoulos, G

Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae Article de journal

Proc. Natl. Acad. Sci. U.S.A., 98 (22), p. 12630–12635, 2001, ISSN: 0027-8424.

Résumé | Liens | BibTeX | Étiquettes: Animals, Anopheles, Anti-Bacterial Agents, Anti-Infective Agents, Base Sequence, Chromosome Mapping, hoffmann, Insect Proteins, Insect Vectors, M3i, Malaria, messenger, RNA

Lamberty, M; Zachary, Daniel; Lanot, R; Bordereau, C; Robert, A; Hoffmann, Jules A; Bulet, Philippe

Insect immunity. Constitutive expression of a cysteine-rich antifungal and a linear antibacterial peptide in a termite insect. Article de journal

J. Biol. Chem., 276 (6), p. 4085–4092, 2001, ISSN: 0021-9258.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Antifungal Agents, Base Sequence, Chromatography, Cysteine, DNA Primers, High Pressure Liquid, hoffmann, Immunohistochemistry, Isoptera, M3i, Peptides, Protein Conformation, Recombinant Proteins, Sequence Homology

Boulanger, Nathalie; Ehret-Sabatier, Laurence; Brun, R; Zachary, Daniel; Bulet, Philippe; Imler, Jean-Luc

Immune response of Drosophila melanogaster to infection with the flagellate parasite Crithidia spp Article de journal

Insect Biochemistry and Molecular Biology, 31 (2), p. 129–137, 2001, ISSN: 0965-1748.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Crithidia, Defensins, Gene Expression, Glycopeptides, Hemocytes, imler, Insect Proteins, M3i, Phagocytosis

2000

Tauszig, Servane; Jouanguy, Emmanuelle; Hoffmann, Jules A; Imler, Jean-Luc

Toll-related receptors and the control of antimicrobial peptide expression in Drosophila Article de journal

Proceedings of the National Academy of Sciences of the United States of America, 97 (19), p. 10520–10525, 2000, ISSN: 0027-8424.

Résumé | Liens | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Blotting, Cell Line, Cell Surface, hoffmann, imler, M3i, Membrane Glycoproteins, Multigene Family, Northern, Peptides, Receptors, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors

Hetru, Charles; Letellier, L; Oren, Z; Hoffmann, Jules A; Shai, Y

Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action Article de journal

Biochem. J., 345 Pt 3 , p. 653–664, 2000, ISSN: 0264-6021.

Résumé | BibTeX | Étiquettes: Adenosine Triphosphate, Anti-Bacterial Agents, Cations, Cell Membrane Permeability, Cytoplasm, Disulfides, Electron, Escherichia coli, Fluoresceins, Fluorescent Dyes, Fourier Transform Infrared, Gram-Negative Bacteria, hoffmann, Insect Proteins, Liposomes, M3i, Microbial Sensitivity Tests, Micrococcus luteus, Microscopy, oxygen, Phospholipids, Potassium, Proteins, spectroscopy

1998

Taguchi, S; Bulet, Philippe; Hoffmann, Jules A

A novel insect defensin from the ant Formica rufa Article de journal

Biochimie, 80 (4), p. 343–346, 1998, ISSN: 0300-9084.

Résumé | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Ants, Chromatography, High Pressure Liquid, hoffmann, Insect Proteins, insects, M3i, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Structure, Secondary, Sequence Alignment, Sequence Homology, Spectrometry

1996

Ehret-Sabatier, L; Loew, D; Goyffon, M; Fehlbaum, P; Hoffmann, Jules A; van Dorsselaer, A; Bulet, Philippe

Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood Article de journal

J. Biol. Chem., 271 (47), p. 29537–29544, 1996, ISSN: 0021-9258.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Chromatography, Cysteine, Electron, Hemolymph, Hemolysis, High Pressure Liquid, hoffmann, M3i, Mass Spectrometry, Microscopy, Peptides, Scorpions

Lowenberger, C A; Ferdig, M T; Bulet, Philippe; Khalili, S; Hoffmann, Jules A; Christensen, B M

Aedes aegypti: induced antibacterial proteins reduce the establishment and development of Brugia malayi Article de journal

Exp. Parasitol., 83 (2), p. 191–201, 1996, ISSN: 0014-4894.

Résumé | Liens | BibTeX | Étiquettes: Aedes, Analysis of Variance, Animals, Anti-Bacterial Agents, Base Sequence, Blood Proteins, Blotting, Brugia malayi, Culicidae, Defensins, DNA, Escherichia coli, Fat Body, Genetic, Gerbillinae, hoffmann, M3i, Micrococcus luteus, Microfilaria, Northern, RNA, Transcription

Fehlbaum, P; Bulet, Philippe; Chernysh, S; Briand, J P; Roussel, J P; Letellier, L; Hetru, Charles; Hoffmann, Jules A

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides Article de journal

Proc. Natl. Acad. Sci. U.S.A., 93 (3), p. 1221–1225, 1996, ISSN: 0027-8424.

Résumé | BibTeX | Étiquettes: Amino Acid, Amphibian Proteins, Animals, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Cyclic, Fungi, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, hoffmann, M3i, Mass Spectrometry, Microbial Sensitivity Tests, Peptides, Ranidae, Sequence Homology, Skin, Structure-Activity Relationship

1995

Lemaitre, Bruno; Kromer-Metzger, E; Michaut, Lydia; Nicolas, E; Meister, Marie; Georgel, Philippe; Reichhart, Jean-Marc; Hoffmann, Jules A

A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense Article de journal

Proc. Natl. Acad. Sci. U.S.A., 92 (21), p. 9465–9469, 1995, ISSN: 0027-8424.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Bacterial Infections, Base Sequence, Gene Expression Regulation, Genes, Glycopeptides, hoffmann, Insect, Insect Hormones, Insect Proteins, M3i, Male, Mutation, Mycoses, Nucleic Acid, Peptides, Protein Binding, Recessive, Regulatory Sequences, reichhart, Reporter, Survival Analysis

Levashina, Elena A; Ohresser, S; Bulet, Philippe; Reichhart, Jean-Marc; Hetru, Charles; Hoffmann, Jules A

Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties Article de journal

Eur. J. Biochem., 233 (2), p. 694–700, 1995, ISSN: 0014-2956.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Antifungal Agents, Antimicrobial Cationic Peptides, bacteria, Base Sequence, Cells, Chromosome Mapping, Cloning, Cultured, Genetic, hoffmann, M3i, Molecular, Peptides, Proline, reichhart, Transcription

Lowenberger, C; Bulet, Philippe; Charlet, Maurice; Hetru, Charles; Hodgeman, B; Christensen, B M; Hoffmann, Jules A

Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti Article de journal

Insect Biochem. Mol. Biol., 25 (7), p. 867–873, 1995, ISSN: 0965-1748.

Résumé | BibTeX | Étiquettes: Aedes, Amino Acid, Animals, Anti-Bacterial Agents, Blood Proteins, Defensins, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, hoffmann, Immunity, Insect Vectors, M3i, Micrococcus luteus, Sequence Homology, Stereoisomerism

Bulet, Philippe; Hegy, G; Lambert, J; van Dorsselaer, Alan; Hoffmann, Jules A; Hetru, Charles

Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity Article de journal

Biochemistry, 34 (22), p. 7394–7400, 1995, ISSN: 0006-2960.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Carbohydrate Sequence, Carbohydrates, Diptera, Escherichia coli, Glycopeptides, Hemolymph, hoffmann, Insect Hormones, Insect Proteins, Larva, M3i, Mass Spectrometry, Plants, Trisaccharides

Hoffmann, Jules A

Innate immunity of insects Article de journal

Curr. Opin. Immunol., 7 (1), p. 4–10, 1995, ISSN: 0952-7915.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Blood Proteins, Cellular, Defensins, Gene Expression Regulation, hoffmann, Immunity, Innate, insects, M3i, Peptides

Lemaitre, Bruno; Meister, Marie; Govind, S; Georgel, Philippe; Steward, R; Reichhart, Jean-Marc; Hoffmann, Jules A

Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila Article de journal

EMBO J., 14 (3), p. 536–545, 1995, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Anti-Infective Agents, Antimicrobial Cationic Peptides, Biological Transport, Cell Nucleus, Cell Surface, DNA-Binding Proteins, Fat Body, Gene Expression Regulation, Genetic, hoffmann, Immunity, Immunohistochemistry, Insect Hormones, Insect Proteins, M3i, Melanins, Membrane Glycoproteins, Mutation, Neoplasms, Nuclear Proteins, Phosphoproteins, Receptors, reichhart, Signal Transduction, Toll-Like Receptors, Transcription, Transcription Factors

1994

Cociancich, S; Dupont, A; Hegy, G; Lanot, R; Holder, F; Hetru, Charles; Hoffmann, Jules A; Bulet, Philippe

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus Article de journal

Biochem. J., 300 ( Pt 2) , p. 567–575, 1994, ISSN: 0264-6021.

Résumé | BibTeX | Étiquettes: Amino Acid, Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Proteins, Chromatography, Defensins, Gas Chromatography-Mass Spectrometry, Gel, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemiptera, Hemolymph, hoffmann, Insect Proteins, M3i, Peptides, Sequence Homology

1993

Bulet, Philippe; Dimarcq, Jean-Luc; Hetru, Charles; Lagueux, Marie; Charlet, Maurice; Hegy, G; Dorsselaer, Alan Van; Hoffmann, Jules A

A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution Article de journal

J. Biol. Chem., 268 (20), p. 14893–14897, 1993, ISSN: 0021-9258.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Base Sequence, Carbohydrates, Cloning, DNA, Escherichia coli, Gas Chromatography-Mass Spectrometry, Glycopeptides, Glycosylation, hoffmann, M3i, Molecular

Hoffmann, Jules A; Hetru, Charles; Reichhart, Jean-Marc

The humoral antibacterial response of Drosophila Article de journal

FEBS Lett., 325 (1-2), p. 63–66, 1993, ISSN: 0014-5793.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Base Sequence, Genes, hoffmann, Insect, Insect Hormones, Insect Proteins, M3i, reichhart, Sequence Homology

Kappler, Christine; Meister, Marie; Lagueux, Marie; Gateff, E; Hoffmann, Jules A; Reichhart, Jean-Marc

Insect immunity. Two 17 bp repeats nesting a kappa B-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila Article de journal

EMBO J., 12 (4), p. 1561–1568, 1993, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Base Sequence, Cloning, Gene Expression Regulation, Genes, Genetic, Genetically Modified, hoffmann, Insect, Insect Hormones, Insect Proteins, Lipopolysaccharides, M3i, messenger, Molecular, NF-kappa B, Nucleic Acid, Oligodeoxyribonucleotides, Promoter Regions, Regulatory Sequences, reichhart, RNA, Transfection

1992

Bulet, Philippe; Cociancich, S; Reuland, M; Sauber, F; Bischoff, R; Hegy, G; Dorsselaer, Van A; Hetru, Charles; Hoffmann, Jules A

A novel insect defensin mediates the inducible antibacterial activity in larvae of the dragonfly Aeschna cyanea (Paleoptera, Odonata) Article de journal

Eur. J. Biochem., 209 (3), p. 977–984, 1992, ISSN: 0014-2956.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Antimicrobial Cationic Peptides, Blood Bactericidal Activity, Blood Proteins, Defensins, Hemolymph, hoffmann, Insect Proteins, insects, Larva, M3i, Mass Spectrometry, Peptides

1990

Dimarcq, Jean-Luc; Zachary, Daniel; Hoffmann, Jules A; Hoffmann, Danièle; Reichhart, Jean-Marc

Insect immunity: expression of the two major inducible antibacterial peptides, defensin and diptericin, in Phormia terranovae Article de journal

EMBO J., 9 (8), p. 2507–2515, 1990, ISSN: 0261-4189.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Base Sequence, Blood Proteins, Cloning, Defensins, Diptera, Gene Expression, hoffmann, Insect Hormones, Insect Proteins, Larva, M3i, Molecular, Nucleic Acid Hybridization, Oligonucleotide Probes, Protein Conformation, reichhart

Wicker, C; Reichhart, Jean-Marc; Hoffmann, Danièle; Hultmark, D; Samakovlis, C; Hoffmann, Jules A

Insect immunity. Characterization of a Drosophila cDNA encoding a novel member of the diptericin family of immune peptides Article de journal

J. Biol. Chem., 265 (36), p. 22493–22498, 1990, ISSN: 0021-9258.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Base Sequence, Cloning, Diptera, DNA, Escherichia coli, hoffmann, Insect Hormones, Insect Proteins, M3i, Molecular, Multigene Family, Nucleic Acid, Oligonucleotide Probes, reichhart, Sequence Homology

1989

Reichhart, Jean-Marc; Essrich, M; Dimarcq, Jean-Luc; Hoffmann, Danièle; Hoffmann, Jules A; Lagueux, Marie

Insect immunity. Isolation of cDNA clones corresponding to diptericin, an inducible antibacterial peptide from Phormia terranovae (Diptera). Transcriptional profiles during immunization Article de journal

Eur. J. Biochem., 182 (2), p. 423–427, 1989, ISSN: 0014-2956.

Résumé | BibTeX | Étiquettes: Animals, Anti-Bacterial Agents, Bacterial Proteins, Base Sequence, Blotting, Diptera, DNA, Endoribonucleases, Enterobacter, Enterobacteriaceae, Gene Expression Regulation, Genes, Genetic, hoffmann, Insect Hormones, Insect Proteins, M3i, messenger, MHC Class II, Northern, reichhart, Ribonuclease H, RNA, Transcription

1988

Dimarcq, Jean-Luc; Keppi, E; Dunbar, B; Lambert, J; Reichhart, Jean-Marc; Hoffmann, Danièle; Rankine, S M; Fothergill, J E; Hoffmann, Jules A

Insect immunity. Purification and characterization of a family of novel inducible antibacterial proteins from immunized larvae of the dipteran Phormia terranovae and complete amino-acid sequence of the predominant member, diptericin A Article de journal

Eur. J. Biochem., 171 (1-2), p. 17–22, 1988, ISSN: 0014-2956.

Résumé | BibTeX | Étiquettes: Amino Acids, Animals, Anti-Bacterial Agents, Diptera, Escherichia coli, hoffmann, Insect Hormones, Insect Proteins, Isoelectric Point, Larva, M3i, reichhart

1987

Debono, M; Barnhart, M; Carrell, C B; Hoffmann, Jules A; Occolowitz, J L; Abbott, B J; Fukuda, D S; Hamill, R L; Biemann, K; Herlihy, W C

A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation Article de journal

J. Antibiot., 40 (6), p. 761–777, 1987, ISSN: 0021-8820.

Résumé | BibTeX | Étiquettes: Acylation, Amino Acids, Anti-Bacterial Agents, Chemical Phenomena, Chemistry, Chromatography, Cyclic, Fatty Acids, Gas Chromatography-Mass Spectrometry, High Pressure Liquid, hoffmann, Hydrolysis, M3i, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Conformation, Peptides, Spectrophotometry, Streptomyces